Drug Interactions between acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine and fenfluramine
This report displays the potential drug interactions for the following 2 drugs:
- acetaminophen/caffeine/chlorpheniramine/phenylpropanolamine
- fenfluramine
Interactions between your drugs
phenylpropanolamine fenfluramine
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine and fenfluramine
Using phenylpropanolamine together with fenfluramine is not recommended. Combining these medications may increase the risk of serious heart problems. Contact your doctor if you develop shortness of breath, chest pain or tightness, dizziness, lightheadedness, fainting, and/or swelling of the legs, ankles, or feet. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
phenylpropanolamine caffeine
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine and acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine
Both phenylpropanolamine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
chlorpheniramine fenfluramine
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine and fenfluramine
Using chlorpheniramine together with fenfluramine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
caffeine fenfluramine
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine and fenfluramine
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with inhibitors of CYP450 1A2 or 2D6 may increase the plasma concentrations of fenfluramine. Over 75% of fenfluramine is metabolized to norfenfluramine prior to elimination, primarily by CYP450 1A2, 2B6 and 2D6, but also to a minor extent by CYP450 2C9, 2C19 and 3A4/5. When a single 0.35 mg/kg dose of fenfluramine oral solution was coadministered with 50 mg once daily fluvoxamine (a potent CYP450 1A2 inhibitor) at steady state in healthy volunteers, fenfluramine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 22% and 102%, respectively, while the Cmax and AUC of norfenfluramine decreased by 44% and 22%, respectively. Coadministration with 30 mg once daily paroxetine (a potent CYP450 2D6 inhibitor) at steady state in healthy volunteers increased the Cmax and AUC of fenfluramine by 13% and 81%, respectively, and decreased Cmax and AUC of norfenfluramine by 29% and 13%, respectively. Coadministration with repeated doses of cannabidiol (a weak CYP450 1A2 inhibitor with the potential to also inhibit CYP450 2B6, 2C8, 2C9, and 2C19 at clinically relevant concentrations) increased the Cmax and AUC of fenfluramine by 10% and 59%, respectively, and decreased Cmax and AUC of norfenfluramine by 33% and 22%, respectively. Elevated plasma levels of fenfluramine may increase the risk of serious adverse effects such as valvular heart disease, pulmonary arterial hypertension, blood pressure increases, and serotonin syndrome.
MANAGEMENT: Caution is advised when fenfluramine is used with CYP450 1A2 or 2D6 inhibitors. Patients should be monitored for increased adverse effects, and the dosage of fenfluramine adjusted as necessary.
References
- (2020) "Product Information. Fintepla (fenfluramine)." Zogenix, Inc
- (2023) "Product Information. Fintepla (fenfluramine)." UCB Pharma Ltd, SUPPL-13
Drug and food interactions
acetaminophen food
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine
Ask your doctor before using acetaminophen together with ethanol. This can cause serious side effects that affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
chlorpheniramine food
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine
Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlorpheniramine. Do not use more than the recommended dose of chlorpheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
phenylpropanolamine food
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine
Using phenylpropanolamine with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. In addition, you may also be more likely to experience nervous system side effects such as dizziness, drowsiness, depression, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with phenylpropanolamine. Do not use more than the recommended dose of phenylpropanolamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
fenfluramine food
Applies to: fenfluramine
Using fenfluramine with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. In addition, you may also be more likely to experience nervous system side effects such as dizziness, drowsiness, depression, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with fenfluramine. Do not use more than the recommended dose of fenfluramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
phenylpropanolamine food
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine
Both phenylpropanolamine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
caffeine food
Applies to: acetaminophen / caffeine / chlorpheniramine / phenylpropanolamine
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Stimulants
Therapeutic duplication
The recommended maximum number of medicines in the 'stimulants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'stimulants' category:
- acetaminophen/caffeine/chlorpheniramine/phenylpropanolamine
- fenfluramine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.