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Drug Interactions between ACAM2000 and tecovirimat

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

smallpox vaccine tecovirimat

Applies to: ACAM2000 (smallpox vaccine) and tecovirimat

Tecovirimat may interfere with the immune response produced by smallpox vaccine. However, use of tecovirimat with vaccines such as smallpox vaccine has not been studied in humans. Your doctor should be informed of recent medication and vaccination history so that appropriate measures and/or precautions can be taken. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any other medications without first talking to your doctor.

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Drug and food interactions

Moderate

tecovirimat food

Applies to: tecovirimat

Food may increase the absorption of tecovirimat when taken orally, which may lead to higher blood levels of the medication. You should take oral preparations of tecovirimat within 30 minutes after a full meal containing moderate or high fat (approximately 600 calories and 25 g of fat) with 6 to 8 ounces of water.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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