Ustekinumab Dosage

This dosage information may not include all the information needed to use Ustekinumab safely and effectively. See additional information for Ustekinumab.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Psoriasis

For use in the treatment of patients with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy:

Less than 100 kg (220 lbs):
Initial dose: 45 mg subcutaneously once initially and 4 weeks later
Maintenance dose: 45 mg subcutaneously once every 12 weeks

Greater than 100 kg (220 lbs):
Initial dose: 90 mg subcutaneously once initially and 4 weeks later
Maintenance dose: 90 mg subcutaneously once every 12 weeks

In subjects weighing greater than 100 kg, 45 mg was also shown to be effective. However, 90 mg resulted in greater efficacy.

The safety and efficacy of ustekinumab have not been evaluated beyond two years.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Ustekinumab should only be administered by a healthcare provider to patients who will be closely monitored and have regular follow-up visits with a physician.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for ustekinumab. It includes a communication plan. Additional information is available at www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm111350.htm.

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