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Ustekinumab Dosage
This dosage information may not include all the information needed to use Ustekinumab safely and effectively. See additional information for Ustekinumab.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Psoriasis
For use in the treatment of patients with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy:
Less than 100 kg (220 lbs):
Initial dose: 45 mg subcutaneously once initially and 4 weeks later
Maintenance dose: 45 mg subcutaneously once every 12 weeks
Greater than 100 kg (220 lbs):
Initial dose: 90 mg subcutaneously once initially and 4 weeks later
Maintenance dose: 90 mg subcutaneously once every 12 weeks
In subjects weighing greater than 100 kg, 45 mg was also shown to be effective. However, 90 mg resulted in greater efficacy.
The safety and efficacy of ustekinumab have not been evaluated beyond two years.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Ustekinumab should only be administered by a healthcare provider to patients who will be closely monitored and have regular follow-up visits with a physician.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Data not available
Other Comments
The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for ustekinumab. It includes a communication plan. Additional information is available at www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm111350.htm.
