Medication Guide App

Typhoid Vaccine, Live Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Typhoid Prophylaxis

One capsule orally 1 hour before a meal with a cold or lukewarm drink [temperature not to exceed body temperature, e.g., 37 °C (98.6 °F)] on alternate days, e.g., days 1, 3, 5 and 7.

Immunization with all 4 doses should be completed at least 1 week prior to potential exposure to Salmonella typhi.

Usual Pediatric Dose for Typhoid Prophylaxis

>= 6 years: One capsule orally 1 hour before a meal with a cold or lukewarm drink [temperature not to exceed body temperature, e.g., 37 °C (98.6 °F)] on alternate days, e.g., days 1, 3, 5 and 7.

Immunization with all 4 doses should be completed at least 1 week prior to potential exposure to Salmonella typhi.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

Live oral typhoid vaccine is contraindicated in immunosuppressed patients because of their inability to produce an immune response, resulting in severe complications. The vaccine should not be administered during acute febrile or gastrointestinal illnesses. The vaccine should be taken at least 24 hours after doses of antibiotics, sulfonamides, and mefloquine. Vaccination should be deferred during illnesses with persistent nausea and vomiting.

An optimal immune response may not be achieved if the complete immunization schedule is not followed. Vaccinees should be advised to take personal precautions to avoid typhoid exposure (i.e., avoiding contact with or ingestion of contaminated food and water) because typhoid vaccines do not completely protect all recipients and may be overwhelmed by large inocula.

The safety and efficacy of live oral typhoid vaccine has not been established in children under 6 years of age.

Dialysis

No adjustment recommended

Other Comments

The vaccine capsules must be refrigerated to maintain full potency.

There are no data on the immunogenicity of oral typhoid vaccine when administered at the same time or within 30 days of other live virus vaccines. The Advisory Committee on Immunization Practices (ACIP) recommends that if typhoid vaccination is considered necessary, it should not be delayed due to the administration of other virus vaccines.

Adverse reactions should be reported to the U.S. Department of Health and Human Services Vaccine Adverse Event Reporting System (VAERS). Reporting forms and information regarding the completion of the form can be obtained at 1-800-822-7967 (USA).

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