Tetrabenazine Dosage
This dosage information may not include all the information needed to use Tetrabenazine safely and effectively. See additional information for Tetrabenazine.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Huntington Disease
Initial dose: 12.5 mg orally 2 to 3 times daily.
Maximum dose: 25 mg orally 3 times daily; maximum recommended dose 200 mg daily.
The dose may be slowly titrated upwards by 12.5 mg a day every 3 to 5 days until the maximal tolerated and effective dose is achieved.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Tetrabenazine is contraindicated in patients with hepatic impairment.
Precautions
Patients should be genotyped for CYP450 2D6 prior to treatment with daily doses of tetrabenazine over 50 mg. Patients who are poor metabolizers should not be given daily doses greater than 50 mg.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Data not available
Other Comments
The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for tetrabenazine. It includes a Medication Guide and communication plan. Additional information is available at www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm111350.htm.
