Rimegepant Dosage

Medically reviewed by Drugs.com. Last updated on Mar 21, 2024.

Usual Adult Dose for Migraine

For Acute Treatment of Migraine: 75 mg orally as needed
Maximum dose: 75 mg in a 24-hour period

Comments:

• The safety of using more than 18 doses in a 30-day period is unknown.

Use: For the acute treatment of migraine with or without aura.

Usual Adult Dose for Migraine Prophylaxis

75 mg orally every other day

Use: For the preventative treatment of episodic migraine.

Renal Dose Adjustments

Mild to Severe Renal Impairment (CrCl 15 mL/min or greater): No adjustment recommended
ESRD (CrCl less than 15 mL/min): Avoid use

Liver Dose Adjustments

Mild to Moderate Hepatic Impairment (Child-Pugh A or B): No adjustment recommended
Severe Hepatic Impairment (Child-Pugh C): Avoid use

Dose Adjustments

Concomitant Use with CYP450 3A4 Inhibitors:

• Strong CYP450 3A4 inhibitors: Avoid concomitant administration
• Moderate CYP450 3A4 inhibitors: Avoid a second dose of this drug within 48 hours

Concomitant Use with CYP450 3A4 Inducers:

• Strong or moderate CYP450 3A4 inducers: Avoid concomitant administration as this may lead to loss of efficacy of this drug

Concomitant Use with P-gp or BCRP:

• Avoid concomitant administration with P-gp or BCRP inhibitors

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to active substance or any product excipients; delayed serious hypersensitivity has occurred

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Place on tongue (or under tongue) and allow to disintegrate in saliva and swallow; additional liquid is not necessary.
• Do not take more than 1 dose in 24-hours.

Storage requirements:

• Store at room temperature, 20C to 25C (68F to 77F); with excursions permitted between 15C to 30C (59F to 86F).

Preparation techniques:

• Use dry hands when opening the blister pack.
• Peel back the foil and gently remove the tablet; do not push tablet through foil.
• Place tablet on tongue or under tongue as soon as the blister is opened; do not store tablet outside the blister pack for future use.

General:

• A pregnancy exposure registry is available. Healthcare providers or patients are encouraged to contact: 1-877-366-0324, email nurtecpregnancyregistry@ppd.com, or visit nurtecpregnancyregistry.com.

Patient advice:

• Read the US FDA-approved patient labeling (Patient Information).
• Contact your healthcare provider if you experience signs or symptoms of an allergic reaction.
• Speak with your healthcare provider about all other medicines you are taking including over the counter medications and herbal supplements.
• Speak with your healthcare provider if you become pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed during therapy.

Frequently asked questions

• How do Ubrelvy, Qulipta and Nurtec compare for migraines?
• What are the new drugs for the treatment of migraines?
• How fast and effective is Nurtec ODT for migraines?
• Does Nurtec ODT cause weight gain?
• How often can you take Nurtec ODT?
• What is the mechanism of action for Nurtec ODT?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer