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Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Arrhythmias
Loading dose: 15 to 18 mg/kg administered as slow infusion over 25 to 30 minutes or 100 mg/dose at a rate not to exceed 50 mg/minute repeated every 5 minutes as needed to a total dose of 1 gram.
Maintenance dose: 1 to 4 mg/minute by continuous infusion. Maintenance infusions should be reduced by one-third in patients with moderate renal or cardiac impairment and by two-thirds in patients with severe renal or cardiac impairment.
ACLS guidelines: Loading dose: Infuse 20 mg/minute (up to 50 mg/minute for more urgent situations) until arrhythmia is controlled, hypotension occurs, QRS complex widens by 50% of its original width, or total of 17 mg/kg is given. Note: Not recommended for use in ongoing ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT) due to prolonged administration time and uncertain efficacy. Follow with maintenance dose as continuous infusion.
50 mg/kg divided into fractional amounts of 1/8 to 1/4 and injected every 3 to 6 hours or 0.5 to 1 gram every 4 to 8 hours.
Oral: ORAL procainamide is not available in the US but is available in Canada.
40 to 50 kg:
Immediate-release: 250 mg orally every 3 hours.
Sustained-release: 500 mg every 6 hours.
Twice daily formulation: 1000 mg every 12 hours.
60 to 70 kg:
Immediate-release: 375 mg every 3 hours.
Sustained-release: 750 mg every 6 hours.
Twice daily formulation: 1500 mg every 12 hours.
80 to 90 kg:
Immediate-release: 500 mg every 3 hours.
Sustained-release: 1000 mg every 6 hours.
Twice daily formulation: 2000 mg every 12 hours.
100 kg or more (Immediate-release) 625 mg every 3 hours.
Sustained-release: 1250 mg every 6 hours.
Twice daily formulation: 2500 mg every 12 hours.
Usual Pediatric Dose for Arrhythmias
less than 1 month:
Loading dose: 7 to 10 mg/kg IV infused over 60 minutes followed by a continuous IV infusion of 20 to 80 mcg/kg/minute; a retrospective study of 20 neonates (GA: 25 weeks or older) reported a mean loading dose of 9.6 Â± 1.5 mg/kg and a mean continuous infusion rate of 37.56 Â± 13.52 mcg/kg/minute. Note: Procainamide serum concentrations were supratherapeutic in five neonates studied; four of the five were less than 36 weeks GA and all five had Clcr less than 30 mL/minute/1.73 m2; these results indicate that doses may need to be decreased in preterm neonates and in those with renal impairment.
1 year or older:
Oral: (ORAL procainamide is not available in the US but is available in Canada.)
15 to 50 mg/kg/day divided every 3 to 6 hours. Maximum 4 g/day.
loading dose: 3 to 6 mg/kg over 5 minutes (not to exceed 100 mg per dose), may repeat every 5 to 10 minutes to maximum total loading dose of 15 mg/kg; do not exceed 500 mg in 30 minutes.
maintenance dose: continuous IV infusion: 20 to 80 mcg/kg/minute; maximum dose: 2 g/day.
20 to 30 mg/kg/day divided every 4 to 6 hours. Maximum 4 g/day.
Stable wide complex tachycardia of unknown origin (atrial or ventricular) or SVT (PALS, 2010): Note: Avoid or use extreme caution when administering procainamide with other drugs that prolong QT interval (e.g., amiodarone); consider consulting with expert.
Loading dose: 15 mg/kg infused intravenously over 30 to 60 minutes; monitor ECG and blood pressure; stop the infusion if hypotension occurs or QRS complex widens by more than 50% of baseline
Renal Dose Adjustments
CrCl less than 10 mL/min: A dosing interval of every 8 to 24 hours is recommended.
CrCl 10 to 50 mL/min: A dosing interval of every 6 to 12 hours is recommended.
Reduce loading dose to 12 mg/kg in severe renal impairment.
Maintenance infusions should be reduced by one-third in patients with moderate renal impairment and by two-thirds in patients with severe renal impairment.
Liver Dose Adjustments
A 50% reduction in the dose is recommended.
Patients with congestive heart failure should receive 2/3 of the loading dose.
Patients that have a slow acetylator phenotype should receive 2/3 of the maintenance dose.
Patients that have a fast acetylator phenotype should receive 1/3 higher maintenance dose.
Moderately hemodialyzable (20% to 50%):
Monitor procainamide/N-acetylprocainamide (NAPA) levels; a 200 mg supplemental dose post-hemodialysis may be necessary.
NAPA: Not dialyzable (0% to 5%)
Procainamide/NAPA: Not peritoneal dialyzable (0% to 5%)
Procainamide/NAPA: Replace by blood level during continuous arteriovenous or venovenous hemofiltration.
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