Prednisone Dosage

Usual Adult Dose for Nephrotic Syndrome

Initial (first three episodes): 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times/day until urine is protein free for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks.
Maintenance dose for frequent relapses: 0.5 to 1 mg/kg/ dose given every other day for 3 to 6 months.

Usual Adult Dose for Anti-inflammatory

5 to 60 mg per day in divided doses 1 to 4 times/day.

Usual Pediatric Dose for Nephrotic Syndrome

Initial (first three episodes): 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times/day until urine is protein free for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks.
Maintenance dose for frequent relapses: 0.5 to 1 mg/kg/ dose given every other day for 3 to 6 months.

Usual Pediatric Dose for Asthma

< I year:
acute: 10 mg orally every 12 hours.
maintenance: 10 mg orally very other day.

1 to 4 years:
acute: 20 mg orally every 12 hours.
maintenance: 20 mg orally every other day.

5 to 12 years:
acute: 30 mg orally every 12 hours.
maintenance: 30 mg orally every other day.

>12 years:
acute: 40 mg orally every 12 hours.
maintenance: 40 mg orally every other day.

Usual Pediatric Dose for Anti-inflammatory

0.05 to 2 mg/kg/day divided 1 to 4 times/day

Usual Pediatric Dose for Immunosuppression

0.05 to 2 mg/kg/day divided 1 to 4 times/day

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Prednisone is inactive and must be metabolized by the liver to prednisolone. This may be impaired in patients with liver disease.

Dose Adjustments

Dosage adjustment should be based on severity of condition treated and response of patient.

Precautions

Avoid abrupt withdrawal after long-term therapy.

Dialysis

Supplemental dose is not necessary.

Other Comments

Administer with meals to reduce gastrointestinal upset.

See also...