Potassium Phosphate / Sodium Phosphate Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypophosphatemia

1 to 2 capsules, tablets, or packets (250 to 500 mg phosphorus (8 to 16 mmol)) orally 4 times a day after meals and at bedtime.

Usual Adult Dose for Urinary Acidification

1 to 2 capsules, tablets, or packets (250 to 500 mg phosphorus (8 to 16 mmol)) orally 4 times a day after meals and at bedtime.

Usual Pediatric Dose for Hypophosphatemia

Neonatal: (Note: Consider the contribution of potassium when determining the appropriate phosphate replacement). Phosphorus Estimated Average Requirement (EAR): Oral: 3.2 mmol/day (adequate intake)

Note: Consider the contribution of sodium and potassium cations when determining appropriate phosphate replacement:
Phosphorus: Recommended Daily Allowance (RDA) and Estimated Average Requirement (EAR):
1 to 6 months: EAR: 3.2 mmol/day (adequate intake)
7 to 12 months: EAR: 8.9 mmol/day (adequate intake)
1 to 3 years: RDA: 14.8 mmol/day; EAR: 12.3 mmol/day
4 to 8 years: RDA: 16.1 mmol/day; EAR: 13.1 mmol/day
9 to 18 years: RDA: 40.3 mmol/day; EAR: 34 mmol/day

Maintenance: Oral:
Children: 2 to 3 mmol/kg/day in divided doses

Laxative: Oral: Uro-KP-Neutral (R):
Children less than or equal to 4 years: 1 capsule or packet (250 mg phosphorus/8 mmol) 4 times/day; dilute as instructed
Children 4 years and older: 1 to 2 capsules or packets (250 to 500 mg phosphorus/8 to 16 mmol) 4 times/day; dilute as instructed

Usual Pediatric Dose for Urinary Acidification

Neonatal: (Note: Consider the contribution of potassium when determining the appropriate phosphate replacement). Phosphorus Estimated Average Requirement (EAR): Oral: 3.2 mmol/day (adequate intake)

Note: Consider the contribution of sodium and potassium cations when determining appropriate phosphate replacement:
Phosphorus: Recommended Daily Allowance (RDA) and Estimated Average Requirement (EAR):
1 to 6 months: EAR: 3.2 mmol/day (adequate intake)
7 to 12 months: EAR: 8.9 mmol/day (adequate intake)
1 to 3 years: RDA: 14.8 mmol/day; EAR: 12.3 mmol/day
4 to 8 years: RDA: 16.1 mmol/day; EAR: 13.1 mmol/day
9 to 18 years: RDA: 40.3 mmol/day; EAR: 34 mmol/day

Maintenance: Oral:
Children: 2 to 3 mmol/kg/day in divided doses

Laxative: Oral: Uro-KP-Neutral (R):
Children less than or equal to 4 years: 1 capsule or packet (250 mg phosphorus/8 mmol) 4 times/day; dilute as instructed
Children 4 years and older: 1 to 2 capsules or packets (250 to 500 mg phosphorus/8 to 16 mmol) 4 times/day; dilute as instructed

Renal Dose Adjustments

CrCl < 30 mL/min: not recommended

Liver Dose Adjustments

Potassium phosphate-sodium phosphate should be carefully considered prior to initiation of therapy in patients with cirrhosis of the liver or severe liver dysfunction.

Precautions

Potassium phosphate-sodium phosphate should not be used in patients with hyperphosphatemia, Addison's disease, infected urolithiasis, struvite stone formation, or in patients with severely impaired renal function.

Potassium phosphate-sodium phosphate should be used with caution in patients with hyperkalemia, metabolic acidosis, cardiac disease, and renal disease.

Potassium phosphate-sodium phosphate dosage forms should be diluted as instructed prior to administration.

Dialysis

Contraindicated in patients with CrCl < 30 mL/min.

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