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Opsynvi Dosage

Generic name: MACITENTAN 10mg, TADALAFIL 20mg
Dosage form: tablet, film coated
Drug class: Agents for pulmonary hypertension

Medically reviewed by Drugs.com. Last updated on Mar 22, 2024.

Recommended Dosage

OPSYNVI is taken orally once daily with or without food. Swallow the tablets whole, with water. Do not cut, crush, or chew tablets. If the patient misses a dose of OPSYNVI, tell the patient to take it as soon as possible and then take the next dose at the regularly scheduled time. Tell the patient not to take two doses at the same time if a dose has been missed.

For patients who are treatment-naïve to any PAH specific therapy or transitioning from ERA monotherapy

The recommended starting dose of OPSYNVI is one 10 mg/20 mg tablet taken orally once daily with or without food for one week. If tolerated, up titrate OPSYNVI to one 10 mg/40 mg tablet taken orally once daily with or without food as the maintenance dose.

For patients transitioning from PDE5 inhibitor monotherapy or PDE5 inhibitor and ERA therapy in combination

The recommended dose of OPSYNVI is one 10 mg/40 mg tablet taken orally once daily.

Pregnancy Testing in Females of Reproductive Potential

Obtain a pregnancy test in females of reproductive potential prior to OPSYNVI treatment, monthly during treatment and one month after stopping OPSYNVI. Initiate treatment with OPSYNVI in females of reproductive potential only after a negative pregnancy test [see Contraindications (4.1), Warnings and Precautions (5.1), and Use in Specific Populations (8.3)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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