Nadolol Dosage

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Usual Adult Dose for Angina Pectoris

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 160 to 240 mg may be needed.

Usual Adult Dose for Hypertension

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 240 to 320 mg may be needed.

Usual Adult Dose for Parkinsonian Tremor

Initial dose: 40 to 60 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.

Usual Adult Dose for Anxiety

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 320 mg may be needed.

Usual Adult Dose for Benign Essential Tremor

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 320 mg may be needed.

Usual Adult Dose for Esophageal Variceal Hemorrhage Prophylaxis

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 320 mg may be needed.

Usual Adult Dose for Glaucoma

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 320 mg may be needed.

Usual Adult Dose for Lithium Tremor

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 320 mg may be needed.

Usual Adult Dose for Migraine Prophylaxis

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 320 mg may be needed.

Usual Adult Dose for Supraventricular Tachycardia

Initial dose: 40 mg orally once a day.
Maintenance dose: 40 to 80 mg orally once a day.
Doses up to 320 mg may be needed.

Renal Dose Adjustments

CrCl less than 10 mL/min: Dosing interval of 40 to 60 hours.

CrCl 10 to 30 mL/min: Dosing interval of 24 to 48 hours.

CrCl 31 to 50 mL/min: Dosing interval of 24 to 36 hours.

Liver Dose Adjustments

Data not available

Dose Adjustments

Dose adjustments may be made in 40 to 80 mg increments at 3 to 7 day intervals.

Precautions

To discontinue, reduce dose gradually over 1 to 2 weeks.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Moderately dialyzable (20 to 50%) via hemodialysis. A supplemental dose or postdialysis dose is recommended.

Supplemental dose is not necessary following peritoneal dialysis.

Other Comments

Compared with Caucasian patients, Black patients have a reduced blood pressure response to monotherapy with beta blockers; however, the reduced response is largely eliminated if combination therapy that includes an adequate dose of a diuretic is instituted.

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