Hydrochlorothiazide / Lisinopril Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Congestive Heart Failure

Initial dose: 1 tablet of (hydrochlorothiazide-lisinopril 12.5 mg/10 mg) once a day. Determine dosage by individual titration.
Maintenance dose: May increase up to a maximum of 2 tablets of (hydrochlorothiazide-lisinopril 25 mg/20 mg) twice a day.

Usual Adult Dose for Hypertension

Initial dose: 1 tablet of (hydrochlorothiazide-lisinopril 12.5 mg/10 mg) once a day. Determine dosage by individual titration.
Maintenance dose: May increase up to a maximum of 2 tablets of (hydrochlorothiazide-lisinopril 25 mg/20 mg) twice a day.

Renal Dose Adjustments

The usual regimens of therapy with hydrochlorothiazide-lisinopril need not be adjusted as long as patient creatinine clearance is 30 mL/min or greater. In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so hydrochlorothiazide-lisinopril is not recommended.

Liver Dose Adjustments

Thiazide diuretics should be used with caution in patients with hepatic impairment.

Dose Adjustments

The hydrochlorothiazide dose should generally not be increased until 2 to 3 weeks have elapsed.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Lisinopril can be removed by hemodialysis.

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