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Flutamide Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Prostate Cancer

For use in locally confined stage B2-C and stage D2 metastatic carcinoma of the prostate: 250 mg orally every 8 hours.

Usual Adult Dose for Hirsutism

Data has been reported in which 250 mg of flutamide 2 to 3 times daily in combination with oral contraceptives has been used in the treatment of female patients with hirsutism.

However, FDA approved package labeling states that flutamide has no indication for women, and should not be used in this population, particularly for nonserious or non-life threatening conditions.

Renal Dose Adjustments

Data not available.

Liver Dose Adjustments

Data not available.

Dose Adjustments

Consider dosage reduction in patients with liver disease based on desired clinical response and patient tolerance.

Precautions

Elevations in liver function tests have been reported. Rare, sometimes fatal, cases of cholestatic jaundice, massive hepatic necrosis, and hepatic encephalopathy have been reported. Baseline liver function tests and periodic monitoring during therapy is recommended.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available.

Other Comments

Doses > 750 mg/day are not recommended. When treating B2-C prostatic carcinoma, flutamide and LHRH agonists should be started 8 weeks prior to initiating radiation therapy and continued during radiation therapy. When treating single stage D2 metastatic carcinoma, flutamide should be initiated with the LHRH agonist and continued until progression.

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