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Fluorouracil Dosage

Medically reviewed by Drugs.com. Last updated on Aug 14, 2023.

Applies to the following strengths: 50 mg/mL

Usual Adult Dose for Colorectal Cancer

IN COMBINATION WITH LEUCOVORIN, OR IN COMBINATION WITH LEUCOVORIN AND OXALIPLATIN OR IRINOTECAN:
400 mg/m2 by IV bolus on Day 1, followed by 2400 to 3000 mg/m2 as a continuous IV infusion over 46 hours every 2 weeks

WHEN ADMINISTERED IN A BOLUS DOSING REGIMEN IN COMBINATION WITH LEUCOVORIN:
500 mg/m2 by IV bolus on Days 1, 8, 15, 22, 29, and 36 in 8-week cycles

Use: Adenocarcinoma of the colon and rectum

Usual Adult Dose for Breast Cancer

ADMINISTERED AS A COMPONENT OF A CYCLOPHOSPHAMIDE-BASED MULTIDRUG REGIMEN:
500 or 600 mg/m2 IV on Days 1 and 8 every 28 days for 6 cycles

Use: Adenocarcinoma of the breast

Usual Adult Dose for Stomach Cancer

ADMINISTERED AS A COMPONENT OF A PLATINUM-CONTAINING MULTIDRUG CHEMOTHERAPY REGIMEN:
200 to 1000 mg/m2 IV as a continuous infusion over 24 hours; the frequency of dosing in each cycle and the length of each cycle will depend on the dose of fluorouracil and the specific regimen administered

Use: Gastric adenocarcinoma

Usual Adult Dose for Pancreatic Cancer

ADMINISTERED IN COMBINATION WITH LEUCOVORIN OR AS A COMPONENT OF A MULTIDRUG CHEMOTHERAPY REGIMEN THAT INCLUDES LEUCOVORIN:
400 mg/m2 by IV bolus on Day 1, followed by 2400 mg/m2 IV as a continuous infusion over 46 hours every 2 weeks

Use: Pancreatic adenocarcinoma

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Withhold therapy for the following:


Upon resolution or improvement to Grade 1 diarrhea, mucositis, myelosuppression, or palmar-plantar erythrodysesthesia, resume administration at a reduced dose.

There is no recommended dose for resumption of therapy if any of the following adverse reactions occur:

Precautions

CONTRAINDICATIONS:


This drug is not recommended for use in children.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


General:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.