Fludarabine Dosage

This dosage information may not include all the information needed to use Fludarabine safely and effectively. See additional information for Fludarabine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Chronic Lymphocytic Leukemia

IV:
25 mg/m2 IV once over 30 minutes for 5 days every 28 days. Following a maximal tumor response, 3 additional cycles are recommended.

Oral:
40 mg/m2 once daily for 5 days every 28 days
Fludarabine phosphate can be taken either on an empty stomach or with food. The tablets have to be swallowed whole with water; they should not be chewed or broken.

Usual Adult Dose for non-Hodgkin's Lymphoma

25 mg/m2/day for 5 days every 28 days

Usual Pediatric Dose for Malignant Disease

Solid tumors: 7 to 9 mg/m2 IV bolus followed by 20 to 27 mg/m2/day continuous IV infusion for 5 days

Usual Pediatric Dose for Leukemia

Acute leukemia: 10 mg/m2 IV once over 15 minutes followed by continuous IV infusion of 30.5 mg/m2/day for 5 days or 10.5 mg/m2 IV once over 15 minutes followed by continuous IV infusion of 30.5 mg/m2/day for 2 days followed by cytarabine.

Usual Pediatric Dose for Stem Cell Transplant Conditioning

Reduced-intensity conditioning regimen prior to allogenic hematopoietic stem cell transplantation: 30 mg/m2/day for 5 days

Renal Dose Adjustments

CrCl 30-70 mL/min/1.73 m2:
Reduce dose by 20% and monitor closely for toxicity

CrCl less than 30 mL/min/1.73 m2:
IV: Not recommended for use
Oral (adults): Administer 50% of dose.

Liver Dose Adjustments

Caution is recommended

Dose Adjustments

The recommended dose of fludarabine may depend on whether other cytotoxic agents are coadministered. Reference to specific protocols is recommended.

Delay or decrease doses in cases of hematologic or other serious toxicities. In case of hemolysis, treatment should be discontinued.

Neurotoxicity: Consider treatment delay or discontinuation

Precautions

Severe bone marrow suppression, notably anemia, thrombocytopenia and neutropenia have been associated with the use of fludarabine.

Dialysis

There are no data specifically regarding use in dialysis. However, the following guidelines should be noted:

CrCl less than 30 mL/min/1.73 m2:
IV: Not recommended for use
Oral (adults): Administer 50% of dose

Other Comments

It is recommended to monitor the CBC with differential, platelet count, AST, ALT, creatinine, serum albumin, and uric acid during therapy.

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