Dartisla ODT Dosage

Important Dosing Information

• Patients receiving the 1 mg dosage strength of another oral tablet dosage form of glycopyrrolate may be switched to the 0.85 mg dosage strength of DARTISLA ODT [see Dosage Forms and Strengths (3) and Clinical Pharmacology (12.3)].
• Patients receiving the 2 mg dosage strength of another oral tablet dosage form of glycopyrrolate may be switched to the 1.7 mg dosage strength of DARTISLA ODT [see Dosage Forms and Strengths (3) and Clinical Pharmacology (12.3)].

Recommended Dosage

Initial dosage:

• The recommended initial dosage is 0.85 mg orally three times daily (in the morning, early afternoon, and at bedtime).
• Some patients may require 1.7 mg at bedtime to assure overnight control of symptoms.
• For maintenance, a dosage of 0.85 mg orally twice is frequently adequate.

Dosage for patients switching from 2 mg glycopyrrolate products:

• The recommended dosage is 1.7 mg two or three times daily at equally spaced intervals.

• The maximum recommended daily dosage is 6.8 mg.
• Use the lowest effective dosage to control symptoms.

Administration Instructions

• Administer DARTISLA ODT at least one hour before or two hours after food [see Clinical Pharmacology (12.3)].
• Use dry hands when opening the blister card and do not open the blister until ready to administer.
• Open the package and peel back the foil on the blister to expose the tablet and gently remove from the blister. Do not push the tablet through the foil.
• Do not break or cut the tablet.
• Immediately place the tablet on the tongue, allow it to disintegrate, and swallow without water.