Medication Guide App

Dacarbazine Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Malignant Melanoma

2 to 4.5 mg/kg IV once a day for 10 days, repeated every 4 weeks or 250 mg/m² IV once a day for 5 days, repeated every 3 weeks.

Usual Adult Dose for Hodgkin's Disease

150 mg/m² IV once a day for 5 days, repeated every 4 weeks or 375 mg/m² IV once, repeated every 15 days in combination therapy.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Doses are based on ideal body weight. Doses may depend upon the specific indication for use.

Precautions

Restriction of oral intake for 4 to 6 hours prior to treatment may help prevent GI adverse reactions. Dacarbazine should be used with caution in patients with renal and/or liver dysfunction.

Dialysis

Data not available

Other Comments

The hematologic profile should be monitored. Hematopoietic toxicity may warrant suspension or cessation of therapy. Patients should be advised to use sunscreens and to avoid sun exposure following administration of this drug.

Hide
(web1)