Chloral Hydrate Dosage

This dosage information may not include all the information needed to use Chloral Hydrate safely and effectively. See additional information for Chloral Hydrate.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Insomnia

500 mg to 1 g 15 to 30 minutes before bedtime.

Usual Adult Dose for Sedation

250 mg 3 times daily after meals, or

500 mg to 1 g 30 minutes before surgery

Usual Pediatric Dose for Insomnia

Oral, Rectal:
Hypnotic: 50 mg/kg/dose at bedtime
Maximum dose: 1 g/dose
Total maximum: 1 g/day for infants and 2 g/day for children

Usual Pediatric Dose for Sedation

Neonatal: Oral, Rectal:
For sedation prior to a procedure: 25 mg/kg. Repeat doses should be used with great caution as drug and metabolites accumulate with repeated use; toxicity has been reported after 3 days in a preterm neonate and after 7 days in a term neonate receiving chloral hydrate 40 to 50 mg/kg every 6 hours.

Infants and Children:
Oral, Rectal:
Sedation, anxiety: 25 to 50 mg/kg/day divided every 6 to 8 hours
Maximum dose: 500 mg/dose
Prior to EEG: 25 to 50 mg/kg/dose 30 to 60 minutes prior to EEG; may repeat in 30 minutes to a total maximum of 100 mg/kg or 1 g total for infants and 2 g total for children.
Sedation, nonpainful procedure: 50 to 75 mg/kg/dose 30 to 60 minutes prior to procedure; may repeat 30 minutes after initial dose if needed.
Maximum dose: 120 mg/kg or 1 g total for infants and 2 g total for children

Renal Dose Adjustments

Chloral hydrate is contraindicated for use in patients with a creatinine clearance below 50 mL/min.

Liver Dose Adjustments

Contraindicated for use in patients with liver dysfunction.

Precautions

Adults: Single or daily dosages should not exceed 2 grams.

Chloral hydrate may be habit forming. The drug should not be discontinued abruptly.

Dialysis

Chloral hydrate is contraindicated for use in patients with a creatinine clearance below 50 mL/min.

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