Calcium Glubionate Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypocalcemia

15 mL orally 3 times a day before meals. Each 5 mL provides 115 mg of elemental calcium. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Hypoparathyroidism

5 to 15 mL orally 3 times a day before meals. Treatment of this disease may also consist of vitamin D.

Usual Adult Dose for Pseudohypoparathyroidism

5 to 15 mL orally once a day before the morning meal. Treatment of this disease may also consist of vitamin D.

Usual Adult Dose for Osteoporosis

15 mL orally 1 to 3 times a day before meals. Osteoporosis can be affected by increased serum parathyroid hormone, excessive alcohol intake, tobacco use, certain drugs (corticosteroids, anticonvulsants, heparin, thyroid hormone), dietary vitamin D, and weight bearing exercise.

Usual Adult Dose for Osteomalacia

5 to 10 mL orally 3 times a day before meals. Treatment may also include vitamin D.

Usual Pediatric Dose for Hypocalcemia

Neonatal:
Oral:
Adequate intake (AI): 200 mg/day of elemental calcium. Requirements may vary on prematurity, postnatal age, and other clinical factors. Serum calcium concentrations should be monitored closely to determine the specific needs of the patient.
Hypocalcemia (dose depends on clinical condition and serum calcium level):
Dose expressed in mg of elemental calcium: 50 to 150 mg/kg/day in 4 to 6 divided doses
Maximum dose: 1 g/day
Dose expressed in mg of calcium glubionate: 1200 mg/kg/day in 4 to 6 divided doses

Dosing:
Usual Oral:
Adequate intake (AI): Dosage expressed in terms of elemental calcium:
1 to 6 months: 200 mg/day
7 to 12 months: 260 mg/day

Recommended daily allowance (RDA): Dosage expressed in terms of elemental calcium (during pregnancy and lactation, requirements may change):
1 to 3 years: 700 mg/day
4 to 8 years: 1000 mg/day
9 to 18 years: 1300 mg/day

Dietary supplement:
Dosage based on product containing: 1.8 g calcium glubionate/5 mL (115 mg elemental calcium/5 mL):
Infants less than 12 months: 1 teaspoonful 5 times a day. May mix with juice or formula.
Children less than 4 years: 2 teaspoonfuls 3 times a day
Children 4 years and older and Adolescents: 1 tablespoonful 3 times a day

Hypocalcemia (dose depends on clinical condition and serum calcium level):
Dose expressed in mg of elemental calcium:
Children: 45 to 65 mg/kg/day in 4 divided doses

Dose expressed in mg of calcium glubionate:
Infants and Children: 600 to 2000 mg/kg/day in 4 divided doses up to a maximum of 9 g/day

Daily maintenance calcium: IV:
Infants and Children less than 25 kg: 1 to 2 mEq/kg/day
Children 25 to 45 kg: 0.5 to 1.5 mEq/kg/day
Children greater than 45 kg and Adults: 0.2 to 0.3 mEq/kg/day or 10 to 20 mEq/day

Renal Dose Adjustments

Patients with renal dysfunction have an increased risk of hypercalcemia. Periodically checking the serum calcium level, especially if signs or symptoms of hypercalcemia are detected, is recommended.

Liver Dose Adjustments

Data not available

Precautions

Calcium glubionate is contraindicated in patients with renal calculi, galactosemia due to deficiencies of either galactokinase or uridyl transferase, or lactase deficiency.

Dialysis

Calcium is removed by hemodialysis. To ensure a positive net calcium flux into the patient during dialysis, a dialysate calcium concentration of 3 to 3.5 mEq/L is usually required. Mid-dialysis modest hypercalcemia in not uncommon when this concentration is used.

Calcium is removed by peritoneal dialysis. The standard peritoneal dialysate contains 3.5 mEq/L of calcium (in 1.5% dextrose) to maintain a positive calcium balance and to prevent calcium loses. When higher concentrations of dextrose are used, the net calcium balance may be negative because of a greater convective removal of calcium during ultrafiltration, which counterbalances the diffusion of calcium from the dialysate to the patient.

Other Comments

The recommended daily allowance (RDA) of calcium is 800 mg. The RDA for pregnant or lactating women is 1200 mg. Each 1 g of calcium glubionate contains 64 mg elemental calcium, or 3.2 mEq of calcium.

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