Atropine/Diphenoxylate Dosage
This dosage information may not include all the information needed to use Atropine/Diphenoxylate safely and effectively. See additional information for Atropine/Diphenoxylate.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Diarrhea
Initial dose: 2 tablets (or 10 mL of liquid) orally 4 times a day.
Maintenance dose: 2 tablets (or 10 mL of liquid) once a day.
Usual Pediatric Dose for Diarrhea
Initial Dose:
>= 2 years, < 3 years: 1.5 to 3 mL orally 4 times a day
>= 3 years, < 4 years: 2 to 3 mL orally 4 times a day
>= 4 years, < 5 years: 2 to 4 mL orally 4 times a day
>= 5 years, <6 years: 2.5 to 4.5 mL orally 4 times a day
>= 6 years, < 9 years: 2.5 to 5 mL orally 4 times a day
>= 9 years, < 13 years: 3.5 to 5 mL orally 4 times a day
>= 13 years, < 18 years: 10 mL orally 3 times a day, or 2 tablets orally 3 times a day
Maintenance Dose:
as low as one-fourth of the initial daily dose.
The liquid formulation should be used for children under 13 years of age.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Only for patients with mild liver disease.
Initial dose: 1 tablet (or 5 mL of liquid) orally 2 to 4 times a day.
Maintenance dose: 1 tablet (or 5 mL of liquid) once a day.
Dose Adjustments
Most patients will require the initial dosage until control has been achieved, after which the dosage requirement may be reduced.
Precautions
Use with extreme caution in young children. This age group has a greater variability of response and may be predisposed to delayed diphenoxylate toxicity.
Dialysis
No adjustment recommended
Other Comments
The maximum daily dose of diphenoxylate is 20 mg.
Clinical improvement of diarrhea is usually seen within 48 hours.
Patients with renal dysfunction should be monitored for signs of atropine toxicity.
