Anti-Thymocyte Globulin (Rabbit) Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Renal Transplant

1.5 mg/kg/day by IV infusion for 7 to 14 days.

Usual Pediatric Dose for Renal Transplant

The safety and effectiveness of anti-thymocyte globulin in pediatric patients has not been established in controlled trials. However, the dose, efficacy, and adverse event profile are not thought to be different from adults based on limited European studies and US compassionate use.

1.5 mg/kg/day administered by IV infusion for 7 to 14 days.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

The recommended route of administration is intravenous infusion using a high-flow vein and an inline 0.22 micrometer filter.

Anti-thymocyte globulin (rabbit) should be infused over a minimum of 6 hours for the first infusion and over at least 4 hours on subsequent days of therapy.

Premedication with corticosteroids, acetaminophen, and/or an antihistamine 1 hour prior to the infusion is recommended and may reduce the incidence and intensity of side effects during the infusion.

Dialysis

Data not available

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