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Rotarix Disease Interactions

There are 2 disease interactions with Rotarix (rotavirus vaccine).

Major

Rotavirus vaccine (applies to Rotarix) immunodeficiency

Major Potential Hazard, Moderate plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts, Lymphoma

The safety and efficacy of rotavirus vaccine in infants with known primary or secondary immunodeficiencies, including HIV, infants in immunosuppressant therapy, or infants with malignant neoplasm affecting the bone marrow or lymphatic system has not been established. Caution is advised when considering wether to administer this vaccine to such patients or patients with immunodeficient close contacts as there is a potential of transmission of the virus through shedding in stools after vaccination (peak excretion occurring around day 7 after first dose).

References

  1. (2006) "Product Information. RotaTeq (rotavirus vaccine)." Merck & Co., Inc
  2. (2008) "Product Information. Rotarix (rotavirus vaccine)." GlaxoSmithKline
Moderate

Rotavirus vaccine (applies to Rotarix) GI disorders

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diarrhea, Vomiting

The administration of the rotavirus vaccine should be delayed in infants suffering from acute diarrhea or vomiting. Additionally, the effectiveness of this vaccine has not been evaluated in infants with chronic gastrointestinal disorders.

References

  1. (2006) "Product Information. RotaTeq (rotavirus vaccine)." Merck & Co., Inc
  2. (2008) "Product Information. Rotarix (rotavirus vaccine)." GlaxoSmithKline

Rotarix drug interactions

There are 313 drug interactions with Rotarix (rotavirus vaccine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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