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Natpara Disease Interactions

There are 3 disease interactions with Natpara (parathyroid hormone).

Major

Parathyroid hormone/analogs (applies to Natpara) hyperparathyroidism

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hypercalcemia

Patients known to have an underlying hypercalcemic disorder, such as primary hyperparathyroidism, should not be treated with parathyroid hormone and its analogs because of the risk of exacerbating hypercalcemia.

References

  1. (2002) "Product Information. Forteo (teriparatide)." Lilly, Eli and Company
  2. (2015) "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals
  3. (2017) "Product Information. Tymlos (abaloparatide)." Radius Health
Major

Parathyroid hormone/analogs (applies to Natpara) malignancy

Major Potential Hazard, Moderate plausibility. Applicable conditions: Paget's Disease, Neoplasm of Bone

Parathyroid hormone and its analogs should not be used in patients who are at increased baseline risk for osteosarcoma. These agents should only be used if the potential benefits are considered to outweigh the potential risks. Monitor these patients according to clinical guidelines. Patients with bone metastases or a history of skeletal malignancies should not be treated with these agents.

References

  1. (2002) "Product Information. Forteo (teriparatide)." Lilly, Eli and Company
  2. (2015) "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals
  3. (2017) "Product Information. Tymlos (abaloparatide)." Radius Health
Moderate

Parathyroid hormone (applies to Natpara) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Parathyroid hormone is eliminated by the kidney and maximum drug levels increased with renal impairment. No dose adjustment is recommended in patients with mild to moderate renal impairment. No studies have been conducted in patients with severe renal impairment or in renal impairment patients on dialysis. Care and close monitoring should be exercised when using this agent in patients with severe renal impairment or on dialysis.

References

  1. (2015) "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals

Natpara drug interactions

There are 5 drug interactions with Natpara (parathyroid hormone).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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