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Palovarotene Disease Interactions

There are 3 disease interactions with palovarotene.

Moderate

Palovarotene (applies to palovarotene) liver disease

Moderate Potential Hazard, Moderate plausibility.

The use of palovarotene in patients with moderate (Child-Pugh B) and severe hepatic impairment (Child-Pugh C) has not been evaluated. The use of this drug in these patients is not recommended.

References

  1. (2023) "Product Information. Sohonos (palovarotene)." Ipsen Biopharmaceuticals, Inc
Moderate

Palovarotene (applies to palovarotene) psychiatric illness

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Depression, Psychosis, History - Psychiatric Disorder

Patients with a history of psychiatric illness may be more susceptible to the adverse effects including depression, anxiety, mood alterations and suicidal thoughts and behaviors. Monitor closely for development of new or worsening psychiatric symptoms during treatment.

References

  1. (2023) "Product Information. Sohonos (palovarotene)." Ipsen Biopharmaceuticals, Inc
Moderate

Palovarotene (applies to palovarotene) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The use of palovarotene in patients with severe renal impairment (ClCr 15 to 29 mL/min) is not recommended.

References

  1. (2023) "Product Information. Sohonos (palovarotene)." Ipsen Biopharmaceuticals, Inc

Palovarotene drug interactions

There are 193 drug interactions with palovarotene.

Palovarotene alcohol/food interactions

There is 1 alcohol/food interaction with palovarotene.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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