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Odevixibat Disease Interactions

There are 3 disease interactions with odevixibat.

Moderate

Odevixibat (applies to odevixibat) cirrhosis

Moderate Potential Hazard, Moderate plausibility.

The efficacy and safety of odevixibat in patients with clinically significant portal hypertension and in patients with decompensated cirrhosis have not been established.

References

  1. (2021) "Product Information. Bylvay (odevixibat)." Albireo Pharma, Inc.
Moderate

Pemigatinib (applies to odevixibat) hepatic dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The recommended dosage of pemigatinib should be reduced in patients with severe hepatic dysfunction. No dose adjustment is recommended for patients with mild or moderate hepatic impairment.

References

  1. (2020) "Product Information. Pemazyre (pemigatinib)." Incyte Corporation
Moderate

Pemigatinib (applies to odevixibat) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

The recommended dosage of pemigatinib should be reduced in patients with severe renal disease. No dose adjustment is recommended for patients with mild or moderate renal impairment, or those patients with end-stage renal disease receiving intermittent hemodialysis.

References

  1. (2020) "Product Information. Pemazyre (pemigatinib)." Incyte Corporation

Odevixibat drug interactions

There are 16 drug interactions with odevixibat.

Odevixibat alcohol/food interactions

There are 2 alcohol/food interactions with odevixibat.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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