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Neratinib Disease Interactions

There is 1 disease interaction with neratinib.

Major

Neratinib (applies to neratinib) liver dysfunction

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Neratinib is mainly metabolized in the liver and its use has been associated with hepatotoxicity characterized by increased liver enzymes. Patients with severe, preexisting hepatic impairment (Child Pugh Class C) experienced a reduction in neratinib clearance and an increase in C max and AUC. It is recommended to reduce the starting dose of neratinib to 80 mg in patients with severe hepatic impairment (Child Pugh C). Measure total bilirubin, AST, ALT, and alkaline phosphatase prior to starting treatment and monthly for the first 3 months of treatment, then every 3 months while on treatment and as clinically indicated. No dose modifications are recommended for patients with mild to moderate hepatic impairment (Child Pugh A or B).

References

  1. (2017) "Product Information. Nerlynx (neratinib)." Puma Biotechnology, Inc.

Neratinib drug interactions

There are 183 drug interactions with neratinib.

Neratinib alcohol/food interactions

There is 1 alcohol/food interaction with neratinib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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