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Livmarli Disease Interactions

There are 2 disease interactions with Livmarli (maralixibat).

Major

IBAT inhibitors (applies to Livmarli) liver disease

Major Potential Hazard, Moderate plausibility.

Liver function test (LFT) abnormalities included ALT, AST, and/or total/direct bilirubin elevations and occurred in patients given maralixibat. Maralixibat was not tested in patients with clinically significant portal hypertension, decompensated cirrhosis, and/or hepatic decompensation. Baseline LFTs should be obtained prior to starting treatment, and levels should be monitored throughout treatment. Dose adjustments should be considered in patients who develop LFT abnormalities in the absence of alternative etiologies. Treatment discontinuation should be considered in patients with persistent or recurrent LFT abnormalities.

References

  1. (2021) "Product Information. Livmarli (maralixibat)." Mirum Pharmaceuticals, Inc.
Moderate

IBAT inhibitors (applies to Livmarli) fat soluble vitamin deficiency

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Vitamin A Deficiency, Vitamin K Deficiency, Vitamin D Deficiency

Maralixibat may affect fat-soluble vitamin (FSV [e.g., vitamins A, D, E, K]) absorption. Baseline FSV levels should be obtained prior to starting treatment, and levels should be monitored throughout treatment. Patients should undergo supplementation with FSV if a deficiency is diagnosed, and treatment discontinuation should be considered in patients with persistent or worsening FSV deficiency despite supplementation.

References

  1. (2021) "Product Information. Livmarli (maralixibat)." Mirum Pharmaceuticals, Inc.

Livmarli drug interactions

There are 32 drug interactions with Livmarli (maralixibat).

Livmarli alcohol/food interactions

There is 1 alcohol/food interaction with Livmarli (maralixibat).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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