Lepirudin Disease Interactions
There are 7 disease interactions with lepirudin.
- Hemophilia
- Liver disease
- Peptic ulcer disease
- Retinopathy
- Subacute bacterial endocarditis
- Hypertension
- Kidney disease
Anticoagulants (applies to lepirudin) hemophilia
Major Potential Hazard, High plausibility. Applicable conditions: Coagulation Defect
Anticoagulants should be given with extreme caution to patients with hemophilia or other congenital or acquired bleeding tendencies. The risk of hemorrhage may be increased in these patients.
References
- "Product Information. Lovenox (enoxaparin)." Rhone Poulenc Rorer PROD (2002):
- "Product Information. Heparin Sodium (heparin)." Lilly, Eli and Company PROD (2001):
- Bergqvist D, Burmark US, Frisell J, Hallbook T, Lindblad B, Risberg B, Torngren S, Wallin G "Prospective double-blind comparison between Fragmin and conventional low-dose heparin: thromboprophylactic effect and bleeding complications." Haemostasis 16 Suppl 2 (1986): 11-8
- "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Orgaran (danaparoid)." Organon PROD (2001):
Anticoagulants (applies to lepirudin) liver disease
Major Potential Hazard, High plausibility.
Anticoagulants should be given with extreme caution to patients at increased risk for hemorrhage, including patients who have severe liver disease with impaired hemostasis.
References
- "Product Information. Lovenox (enoxaparin)." Rhone Poulenc Rorer PROD (2002):
- "Product Information. Heparin Sodium (heparin)." Lilly, Eli and Company PROD (2001):
- Bergqvist D, Burmark US, Frisell J, Hallbook T, Lindblad B, Risberg B, Torngren S, Wallin G "Prospective double-blind comparison between Fragmin and conventional low-dose heparin: thromboprophylactic effect and bleeding complications." Haemostasis 16 Suppl 2 (1986): 11-8
- "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Orgaran (danaparoid)." Organon PROD (2001):
Anticoagulants (applies to lepirudin) peptic ulcer disease
Major Potential Hazard, High plausibility.
Anticoagulants are contraindicated in patients with active major bleeding or those patients at risk for hemorrhage. Hemorrhage due to heparin derivatives may be treated with protamine sulfate 1%. However, protamine sulfate may not completely neutralize the anti- Factor Xa activity.
References
- Oates JA, Wood AJJ "Heparin." N Engl J Med 324 (1991): 1565-74
- Nieuwenhuis HK, Albada J, Banga JD, Sixma JJ "Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular weight heparin." Blood 78 (1991): 2337-43
- Walker AM, Jick H "Predictors of bleeding during heparin therapy." JAMA 244 (1980): 1209-12
- Breddin HK "Low molecular weight heparins and bleeding." Semin Thromb Hemost 15 (1989): 401-4
- "Product Information. Lovenox (enoxaparin)." Rhone Poulenc Rorer PROD (2002):
- "Product Information. Heparin Sodium (heparin)." Lilly, Eli and Company PROD (2001):
- Hirsh J, Fuster V "Guide to anticoagulant therapy. 1. Heparin." Circulation 89 (1994): 1449-68
- Sugiyama T, Itoh M, Ohtawa M, Natsuga T "Study on neutralization of low molecular weight heparin (LHG) by protamine sulfate and its neutralization characteristics." Thromb Res 68 (1992): 119-29
- "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Orgaran (danaparoid)." Organon PROD (2001):
Anticoagulants (applies to lepirudin) retinopathy
Major Potential Hazard, High plausibility. Applicable conditions: Diabetic Retinopathy, Hypertensive Retinopathy
The use of anticoagulants may increase the risk of bleeding in patients with hypertensive or diabetic retinopathy. Therapy with anticoagulants should be administered with extreme caution in such patients.
References
- "Product Information. Lovenox (enoxaparin)." Rhone Poulenc Rorer PROD (2002):
- "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn PROD (2001):
Anticoagulants (applies to lepirudin) subacute bacterial endocarditis
Major Potential Hazard, High plausibility. Applicable conditions: Infectious Endocarditis
Anticoagulants should be given with extreme caution to patients with subacute bacterial endocarditis. The risk of hemorrhage may be increased in these patients.
References
- "Product Information. Lovenox (enoxaparin)." Rhone Poulenc Rorer PROD (2002):
- "Product Information. Heparin Sodium (heparin)." Lilly, Eli and Company PROD (2001):
- Bergqvist D, Burmark US, Frisell J, Hallbook T, Lindblad B, Risberg B, Torngren S, Wallin G "Prospective double-blind comparison between Fragmin and conventional low-dose heparin: thromboprophylactic effect and bleeding complications." Haemostasis 16 Suppl 2 (1986): 11-8
- "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Orgaran (danaparoid)." Organon PROD (2001):
Anticoagulants (applies to lepirudin) hypertension
Moderate Potential Hazard, High plausibility.
Anticoagulants should be used with extreme caution in patients at increased risk for hemorrhage, including those patients with severe hypertension.
References
- "Product Information. Lovenox (enoxaparin)." Rhone Poulenc Rorer PROD (2002):
- "Product Information. Heparin Sodium (heparin)." Lilly, Eli and Company PROD (2001):
- "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Orgaran (danaparoid)." Organon PROD (2001):
Anticoagulants (applies to lepirudin) kidney disease
Moderate Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction
Anticoagulants should be given with extreme caution to patients with severe kidney dysfunction. Altered coagulation may increase the risk of bleeding in these patients. If an anticoagulant is administered, these patients should be monitored closely for signs of bleeding.
References
- "Product Information. Lovenox (enoxaparin)." Rhone Poulenc Rorer PROD (2002):
- "Product Information. Heparin Sodium (heparin)." Lilly, Eli and Company PROD (2001):
- Bergqvist D, Burmark US, Frisell J, Hallbook T, Lindblad B, Risberg B, Torngren S, Wallin G "Prospective double-blind comparison between Fragmin and conventional low-dose heparin: thromboprophylactic effect and bleeding complications." Haemostasis 16 Suppl 2 (1986): 11-8
- "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn PROD (2001):
- "Product Information. Orgaran (danaparoid)." Organon PROD (2001):
Lepirudin drug interactions
There are 155 drug interactions with lepirudin.
Lepirudin alcohol/food interactions
There is 1 alcohol/food interaction with lepirudin.
More about lepirudin
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: thrombin inhibitors
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.