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Larotrectinib Disease Interactions

There is 1 disease interaction with larotrectinib.

Moderate

Larotrectinib (applies to larotrectinib) hepatotoxicity/liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Forty- five percent of the patients receiving larotrectinib had increased hepatic parameters, including Grade 3 increased AST or ALT in 6% of patients. Monitor liver tests, including ALT and AST, every 2 weeks during the first month of treatment, then monthly thereafter, and as clinically indicated. Treatment should be withheld or permanently discontinued based on the severity of hepatic toxicity. Caution is advised in patients with moderate to severe hepatic impairment as the drug clearance was reduced in these patients (Child-Pugh B and C). Dose should be reduced on these patients as recommended by the manufacturers (refer to prescribing information).

References

  1. (2018) "Product Information. Vitrakvi (larotrectinib)." Bayer Pharmaceutical Inc

Larotrectinib drug interactions

There are 474 drug interactions with larotrectinib.

Larotrectinib alcohol/food interactions

There is 1 alcohol/food interaction with larotrectinib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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