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Leqvio Disease Interactions

There are 2 disease interactions with Leqvio (inclisiran).

Moderate

Inclisiran (applies to Leqvio) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Inclisiran has not been studied in patients with severe liver dysfunction; caution is recommended. No dose adjustments are needed for patients with mild to moderate liver dysfunction.

References

  1. (2022) "Product Information. Leqvio (inclisiran)." Novartis Pharmaceuticals
Moderate

Inclisiran (applies to Leqvio) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Inclisiran has not been studied in patients with end-stage renal disease; caution is recommended. No dose adjustments are needed for patients with mild, moderate, or severe renal dysfunction.

References

  1. (2022) "Product Information. Leqvio (inclisiran)." Novartis Pharmaceuticals

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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