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Guanidine Disease Interactions

There are 2 disease interactions with guanidine.

Major

Guanidine (applies to guanidine) bone marrow suppression

Major Potential Hazard, High plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts

The use of guanidine has been rarely associated with dose-related bone marrow suppression, sometimes fatal. Therapy with guanidine should be administered cautiously in patients with preexisting bone marrow suppression. Monitoring complete blood cell counts (CBC) and differential counts at baseline and periodically is recommended. Discontinue guanidine if bone marrow suppression occurs. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression, such as fever, sore throat, local infection, bleeding, or symptoms of anemia.

References

  1. "Product Information. Guanidine Hydrochloride (guanidine)." Schering Corporation PROD
Moderate

Guanidine (applies to guanidine) renal function disorders

Moderate Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction

The use of guanidine has been associated with exacerbation of renal dysfunction. Therapy with guanidine should be administered cautiously in patients with preexisting renal disease. Monitoring renal function regularly is recommended.

References

  1. "Product Information. Guanidine Hydrochloride (guanidine)." Schering Corporation PROD

Guanidine drug interactions

There are 49 drug interactions with guanidine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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