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Etranacogene dezaparvovec Disease Interactions

There are 2 disease interactions with etranacogene dezaparvovec.

Moderate

Etranacogene dezaparvovec (applies to etranacogene dezaparvovec) hepatic cancer

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infectious Hepatitis, Liver Disease, Alcoholism

Therapy with etranacogene dezaparvovec may increase the risk of hepatocellular carcinoma development. Patients with preexisting risk factors for hepatocellular cancer such as cirrhosis, advanced hepatic fibrosis, hepatitis B or C, non-alcoholic fatty liver disease, alcoholism, non-alcoholic steatohepatitis, and advanced age should be monitored annually with a liver ultrasound and alpha-fetoprotein testing during 5 years following administration. The safety and efficacy of this drug in patients with severe hepatic impairment has not been studied.

References

  1. (2022) "Product Information. Hemgenix (46-50 kg) (etranacogene dezaparvovec)." CSL Behring LLC
Moderate

Etranacogene dezaparvovec (applies to etranacogene dezaparvovec) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

The safety and efficacy of etranacogene dezaparvovec in patients with severe renal impairment and end-stage renal disease have not been studied. Caution is advised.

References

  1. (2022) "Product Information. Hemgenix (46-50 kg) (etranacogene dezaparvovec)." CSL Behring LLC

Etranacogene dezaparvovec drug interactions

There are 31 drug interactions with etranacogene dezaparvovec.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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