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Difelikefalin Disease Interactions

There is 1 disease interaction with difelikefalin.

Moderate

Difelikefalin (applies to difelikefalin) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of difelikefalin in patients with severe hepatic impairment has not been evaluated and is not recommended. A population pharmacokinetic analysis has shown that dosage adjustments are not needed in patients with mild to moderate hepatic impairment. The metabolism of this drug is unknown.

References

  1. (2021) "Product Information. Korsuva (difelikefalin)." Cara Therapeutics, Inc.

Difelikefalin drug interactions

There are 254 drug interactions with difelikefalin.

Difelikefalin alcohol/food interactions

There is 1 alcohol/food interaction with difelikefalin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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