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Clofazimine Disease Interactions

There are 2 disease interactions with clofazimine.

Moderate

Clofazimine (applies to clofazimine) GI effects

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diarrhea, Inflammatory Bowel Disease

The use of clofazimine has been associated with severe abdominal symptoms including splenic infarction, bowel obstruction, and GI bleeding. Death has been reported following severe abdominal symptoms. Crystalline deposits have been found in the intestinal mucosa, liver, gallbladder, bile, spleen, adrenals, subcutaneous fat, mesenteric lymph nodes, muscles, bone and skin. Clofazimine should be administered cautiously in patients with GI problems such as abdominal pain and diarrhea.

References

  1. Merrett MN, King RW, Farrell KE, Zeimer H, Guli E (1990) "Orange/black discolouration of the bowel (at laparotomy) due to clofazimine." Aust N Z J Surg, 60, p. 638-9
  2. Belaube P, Devaux J, Pizzi M, Boutboul R, Privat Y (1983) "Small bowel deposition of crystals associated with the use of clofazimine (Lamprene) in the treatment of prurigo nodularis." Int J Lepr Other Mycobact Dis, 51, p. 328-30
  3. Venencie PY, Cortez A, Orieux G, Jost JL, Chomette G, Puissant A (1986) "Clofazimine enteropathy." J Am Acad Dermatol, 15, p. 290-1
  4. Holdiness MR (1989) "Clinical pharmacokinetics of clofazimine: a review." Clin Pharmacokinet, 16, p. 74-85
  5. (2002) "Product Information. Lamprene (clofazimine)." Novartis Pharmaceuticals
  6. Ravi S, Holubka J, Veneri R, Youn K, Khatib R (1993) "Clofazimine-induced eosinophilic gastroenteritis in AIDS." Am J Gastroenterol, 88, p. 612-3
  7. Chong PY, Ti TK (1993) "Severe abdominal pain in low dosage clofazimine." Pathology, 25, p. 24-6
View all 7 references
Moderate

Clofazimine (applies to clofazimine) renal dysfunction

Moderate Potential Hazard, High plausibility.

Clofazimine is primarily eliminated by the kidney. Approximately 99% of clofazimine is excreted unchanged in the urine. Therapy with clofazimine should be administered cautiously and may a longer dosing interval in patients with renal dysfunction.

References

  1. Holdiness MR (1989) "Clinical pharmacokinetics of clofazimine: a review." Clin Pharmacokinet, 16, p. 74-85

Clofazimine drug interactions

There are 254 drug interactions with clofazimine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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