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Caplacizumab Disease Interactions

There are 2 disease interactions with caplacizumab.

Moderate

Caplacizumab (applies to caplacizumab) bleeding

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Coagulation Defect

Caplacizumab increases the risk of bleeding. This risk is increased in patients with underlying coagulopathies (e.g., hemophilia, other coagulation factor deficiencies). It is also increased with concomitant use of drugs affecting hemostasis and coagulation. Treatment with caplacizumab should be interrupted if clinically significant bleeding occurs. Caution and close monitoring is advised.

References

  1. (2019) "Product Information. Cablivi (caplacizumab)." Genzyme Corporation
Moderate

Caplacizumab (applies to caplacizumab) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

No formal studies with caplacizumab have been conducted in patients with severe acute or chronic hepatic impairment and no data regarding the use of the drug in these populations are available. Due to a potential increased risk of bleeding, the use of caplacizumab in patients with severe hepatic impairment requires close monitoring.

References

  1. (2019) "Product Information. Cablivi (caplacizumab)." Genzyme Corporation

Caplacizumab drug interactions

There are 155 drug interactions with caplacizumab.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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