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Bivalirudin Disease Interactions

There are 2 disease interactions with bivalirudin.

Major

Thrombin inhibitors (applies to bivalirudin) active bleeding

Major Potential Hazard, High plausibility. Applicable conditions: Coagulation Defect

The use of thrombin inhibitors is contraindicated in the presence of active major bleeding. Additionally, these drugs should be used with caution in patients with disease states associated with an increased risk of bleeding.

References

  1. (2010) "Product Information. Pradaxa (dabigatran)." Boehringer-Ingelheim
  2. (2016) "Product Information. Bivalirudin (bivalirudin)." Fresenius Kabi USA, LLC
Moderate

Bivalirudin (applies to bivalirudin) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Clinical studies showed that the clearance of bivalirudin is reduced approximately 20% with moderate and severe renal impairment and is reduced about 80% in dialysis-dependent patients. The infusion dose of bivalirudin may need to be reduced, and anticoagulant status monitored in patients with renal impairment.

References

  1. (2016) "Product Information. Bivalirudin (bivalirudin)." Fresenius Kabi USA, LLC

Bivalirudin drug interactions

There are 153 drug interactions with bivalirudin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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