Bevyxxa Disease Interactions
There are 4 disease interactions with Bevyxxa (betrixaban).
Betrixaban (applies to Bevyxxa) bleeding
Major Potential Hazard, Moderate plausibility.
The use of betrixaban is contraindicated in patients with active pathological bleeding. Care and close monitoring is recommended when using this agent in patients who are receiving neuraxial anesthesia or undergoing spinal puncture as epidural or spinal hematomas may occur. Consider risk of using this agent when scheduling patients for spinal procedures.
References
- (2017) "Product Information. Bevyxxa (betrixaban)." Portola Pharmaceuticals
Betrixaban (applies to Bevyxxa) hepatic dysfunction
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The use of betrixaban is not recommended in patients with hepatic impairment as these patients may have intrinsic coagulation abnormalities.
References
- (2017) "Product Information. Bevyxxa (betrixaban)." Portola Pharmaceuticals
Betrixaban (applies to Bevyxxa) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Patients with severe renal impairment (CrCl >= 15 to < 30 mL/min computed by Cockcroft-Gault using actual body weight) may have an increased risk of bleeding events. It is recommended to reduce the betrixaban dose in patients with severe renal impairment. Monitor patients closely and promptly evaluate any signs or symptoms of blood loss in these patients. No dose adjustment is needed for mild or moderate renal impairment (CrCl > 30 mL/min, computed by Cockcroft-Gault using actual body weight).
References
- (2017) "Product Information. Bevyxxa (betrixaban)." Portola Pharmaceuticals
Oral anticoagulants (applies to Bevyxxa) antiphospholipid syndrome
Moderate Potential Hazard, Moderate plausibility.
Direct acting oral anticoagulants including factor Xa inhibitors and some thrombin inhibitors as dabigatran, are not recommended for use in patients with antiphospholipid syndrome (APS). Treatment with these drugs has been associated with increased rates of recurrent thrombotic events, especially in patients with triple positive APS.
References
- (2010) "Product Information. Pradaxa (dabigatran)." Boehringer-Ingelheim
- (2022) "Product Information. Xarelto (rivaroxaban)." Janssen Pharmaceuticals, SUPPL-39
- (2021) "Product Information. Eliquis (apixaban)." Bristol-Myers Squibb, SUPPL-34
- (2021) "Product Information. Savaysa (edoxaban)." Daiichi Sankyo, Inc., SUPPL-17
Bevyxxa drug interactions
There are 277 drug interactions with Bevyxxa (betrixaban).
Bevyxxa alcohol/food interactions
There is 1 alcohol/food interaction with Bevyxxa (betrixaban).
More about Bevyxxa (betrixaban)
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- Imprints, shape & color data
- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: factor Xa inhibitors
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.