Trisenox Disease Interactions
There are 2 disease interactions with Trisenox (arsenic trioxide).
Arsenic trioxide (applies to Trisenox) conduction abnormalities
Major Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias, Electrolyte Abnormalities
Arsenic trioxide can cause QTc interval prolongation, complete atrioventricular block, and a torsade de pointes- type ventricular arrhythmia, which can be fatal. Prior to initiating therapy with arsenic trioxide, assess the QTc interval by electrocardiogram, correct pre- existing electrolyte abnormalities, and consider discontinuing drugs known to prolong QTc interval. Arsenic trioxide should not be administered to patients with ventricular arrhythmia or prolonged QTc interval.
References
- "Product Information. Trisenox (arsenic trioxide)." Cephalon Inc PROD (2001):
Arsenic trioxide (applies to Trisenox) encephalopathy
Major Potential Hazard, Moderate plausibility. Applicable conditions: Thiamine Deficiency, Malabsorption Syndrome, Alcoholism
Serious encephalopathy, including Wernicke's, has occurred in patients treated with arsenic trioxide injection. Wernicke's is a neurologic emergency. Consider testing thiamine levels in patients at risk for thiamine deficiency. Administer parenteral thiamine in patients with or at risk for thiamine deficiency. Monitor patients for neurological symptoms and nutritional status while receiving arsenic trioxide injection. If encephalopathy is suspected, immediately interrupt arsenic trioxide injection and initiate parenteral thiamine. Monitor until symptoms resolve or improve and thiamine levels normalize.
References
- "Product Information. Trisenox (arsenic trioxide)." Cephalon Inc PROD (2001):
Trisenox drug interactions
There are 284 drug interactions with Trisenox (arsenic trioxide).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.