Apomorphine Disease Interactions
There are 2 disease interactions with apomorphine.
Dopamine agonists (applies to apomorphine) hypotension
Major Potential Hazard, Moderate plausibility.
Dopamine agonists may impair the systemic regulation of blood pressure, with resultant orthostatic hypotension, especially during dose escalation. Therapy with dopamine agonists should be monitored carefully in patients with Parkinson's disease since they may have an impaired ability to respond to an orthostatic challenge, and also in patients receiving antihypertensive drugs.
References
- Hoehn MM (1975) "Levodopa-induced postural hypotension. Treatment with fludrocortisone." Arch Neurol, 32, p. 50-1
- Iwasaki S, Hamaguchi K, Iwasaki A, Takakusagi M, Narabayashi Y (1990) "Hypotensive effect of long-term levodopa in patients with Parkinson's disease." Eur Neurol, 30, p. 194-9
- (2001) "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn
- (2001) "Product Information. Sinemet (carbidopa-levodopa)." DuPont Pharmaceuticals
- (2001) "Product Information. Sinemet CR (carbidopa-levodopa)." DuPont Pharmaceuticals
- (2001) "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim
- (2001) "Product Information. Requip (ropinirole)." SmithKline Beecham
- (2001) "Product Information. Comtan (entacapone)." Novartis Pharmaceuticals
- (2006) "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA
- (2007) "Product Information. Neupro (rotigotine)." Schwarz Pharma
- (2017) "Product Information. Xadago (safinamide)." US WorldMeds LLC
Dopaminergic antiparkinson agents (applies to apomorphine) psychosis
Major Potential Hazard, Moderate plausibility.
Ordinarily, patients with major psychotic disorder should not be treated with dopaminergic antiparkinson agents, because of the risk of exacerbating psychosis. Hallucinations and psychotic-like behavior have been reported with dopaminergic medications. In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of these drugs.
References
- (2001) "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn
- (2001) "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim
- (2001) "Product Information. Requip (ropinirole)." SmithKline Beecham
- (2001) "Product Information. Comtan (entacapone)." Novartis Pharmaceuticals
- (2001) "Product Information. Lodosyn (carbidopa)." DuPont Pharma
- (2006) "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA
- (2007) "Product Information. Neupro (rotigotine)." Schwarz Pharma
- (2017) "Product Information. Xadago (safinamide)." US WorldMeds LLC
Apomorphine drug interactions
There are 532 drug interactions with apomorphine.
Apomorphine alcohol/food interactions
There is 1 alcohol/food interaction with apomorphine.
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.