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Amifostine Disease Interactions

There are 3 disease interactions with amifostine.

Major

Amifostine (applies to amifostine) dehydration

Major Potential Hazard, High plausibility.

Patients who are dehydrated should not receive amifostine therapy and appropriate hydration prior to administration of amifostine is necessary. Hypotensive episodes have occurred in 62% of patients receiving amifostine. Amifosine reduces the cumulative renal toxicity associated with cisplatin therapy.

References

  1. (2001) "Product Information. Ethyol (amifostine)." Alza
Major

Amifostine (applies to amifostine) hypotension

Major Potential Hazard, Moderate plausibility. Applicable conditions: Ischemic Heart Disease, Cerebral Vascular Disorder, Congestive Heart Failure, Arrhythmias, Dehydration

Patients who are hypotensive or in state of dehydration, or those that are unable to discontinue antihypertensive treatment 24 hours prior to amifostine administration should not receive amifostine. Transient hypotensive episodes have occurred in 62% of patients receiving amifostine. Three percent of patients required discontinuation of amifostine. Therapy with amifostine should be administered cautiously in patients adversely affected by hypotensive effects such as cardiovascular conditions of arrhythmia, angina, or CHF or cerebrovascular conditions of or history of stroke or ischemic attacks. Clinical monitoring of blood pressure is necessary.

References

  1. (2001) "Product Information. Ethyol (amifostine)." Alza
Moderate

Amifostine (applies to amifostine) hypocalcemia

Moderate Potential Hazard, Low plausibility.

Hypocalcemic effects during amifostine therapy are rare, but appear to result from inhibition of parathyroid hormone secretion and bone resorption and from increased urinary calcium elimination. Therapy with amifostine should be administered cautiously in patients with or predisposed to hypocalcemia, including hypoparathyroidism.

References

  1. (2001) "Product Information. Ethyol (amifostine)." Alza

Amifostine drug interactions

There are 120 drug interactions with amifostine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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