Trintellix for Major Depressive Disorder User Reviews (Page 4)

• Ainsley
• Taken for 6 months to 1 year
• September 10, 2023

"For years, I have struggled with suicidal thoughts and countless antidepressants that absolutely did not help, and made me feel worse. I felt better within the first week of taking Trintellix. The only downside is I've been having joint pains caused by the medication, but it isn't as bad after I got my dosage increased to 20mg. Other than that, it helps a lot with my BPD as well! In my opinion, it helps with the rage episodes as well as paranoia to some extent. So not only does it make my MDD feel like it's barely there, but it's also making my BPD more manageable."

• Tired...
• May 6, 2017

"I have been battling major depression and anxiey for years and was at the point of saying this illness is meant to be my fatality. After several tries on different antidepressants. Trintellix has given me a new outlook on life. If you are at the point of tiresome trial and error do not give up until you try Trintellix. The benefits out way the side effects."

• Steph...
• Taken for 1 to 6 months
• December 7, 2014

"I had no ill side effects with this medication. But, my doctor gave me samples, and when the samples were gone, my insurance wouldn't pay for the medication. I came off of it even though it worked because of the cost."

• Anonymous
• Taken for 6 months to 1 year
• August 3, 2015

"I am a 42 yr old mother. I have been depressed all of my life. Never been happy more than a few weeks at a time. I have tired a few different mess but no real change. I would also self medicate with alcohol. At least once a week I would get to drunk I would black out. As you probably figured that caused a lot of problems in itself. I started taken Brentellix 6 moths ago and I have NEVER been so happy in my entire life! I love it! It really changed my life for the better. No more drinking! At all. I'm so happy and my family has also seen the change are are more happy."

• Ottawa...
• February 2, 2016

"Tried many drugs over the past 20 years. This is the best yet. No strange feelings in the head, no twitching muscles or fog. Some stomach discomfort which was solved by splitting the l0 milligram tablet in two and taking morning and afternoon. The quality of my life has improved beautifully, and I am so grateful for it."

• rowan
• August 31, 2018

"I had tried cipralex for a while when I was younger and it helped with my depression but the side effects were unpleasant and unhelpful. I had sexual dysfunction, blunted emotions, and a terrible crash after one beer resulting in weeks of anxiety. I was off and barely scraping by without help for years when I finally saw a new doctor who listened to my story and recommended trintellix. On the first day I noticed my mood improve. Over the weeks the residual anxiety vanished. I felt excited to wake up with the sun for the first time since childhood. The nausea was difficult to cope with, but if I take it before bed when already sleepy I am asleep before the nausea starts. It helped my concentration a little and we added concerta to the mix. I still cry but it's when I have a reason to now. Little things people take for granted, like vacuuming and doing laundry, are possible. It drained my savings but it helped me feel ready to try again. I'm finally employed and getting somewhere again."

• Jenn...
• Taken for less than 1 month
• May 6, 2017

"I have dealt with chronic depression most of my life & I am 65 years young. I have been on so many pharmaceuticals over the years; starting at age of 23 (Valium, Zoloft, Wellbutrin, Paxil, Buspar, Effexor, Pristiq, etc) and Cymbalta for 15 years. Current dose is 90 mg daily (1-60 mg & 1-30 mg). I went to see a Psychiatrist at my Family Practice Docs suggestion we felt I needed a change. I have also had Fibromyalgia for 25 years plus & collected disability. Cymbalta has had the most longevity with me because it also managed my Fibro. 1 month ago I started on 5 mg of Trintellix. No side effects for 2 weeks. Then she bumped up to 10 mg & no side effects except exhausted. Removed 30 mg of Cymbalta & its’ been 2 weeks & I feel great. I feel blessed – no side effects except being tired."

• DebraD
• Taken for less than 1 month
• September 29, 2019

"Only on the Trintellix 5mg for week #1. I feel better already. I was a failed of 2 different other antidepressants. I WAS losing my temper at work, wanting to get even with those who made me mad. I recognized that I needed a change as that was not me. My Dr. told me to take the medication with peanut butter, or at least with a meal so I wouldn’t be sick as it is a side effect. I know I’m only in the first week, but I am getting back to me already, as noted in better hygiene on my days off, actually getting out of bed. I have started cleaning up my house again. Yes it has given me diarrhea some, but I have no gallbladder in which also gave me diarrhea. Simple fix with incorporating yogurt into my daily diet. So far I am very pleased with Trintellix. My insurance company thankfully will cover the medication because of the past failure of the previous 2 I have tried."

• GTL
• Taken for 1 to 6 months
• April 9, 2020

"I’ve tried citalopram, Effexor, Wellbutrin SR and XL and Trintellix for anxiety issues, but all seemed to cause more anxiety and added depression, than I had before I started taking them. Every time I stop taking them I feel significantly better. Other negative side effects for trintellix specifically included nausea (I had to stop eating specific foods and because I was taking the medication with water I felt sick every time I drank it throughout the day), lower sexual appetite (significantly, was affecting my relationship), and lack of focus (I’m honestly lucky that I didn’t lose my job the week before I stopped taking them). I know I’ve had anxiety my whole life but the more I observe my issues, I’m fairly certain that the majority of my anxiety is caused by ADD."

• Gio
• December 16, 2014

"I was admitted into a clinic & was monitored for 3 weeks. After the 2nd day I started feeling a change & after 4 weeks it's still good. Energy levels are up, thinking positively & coping with society & life again. Only downfall for me is trouble sleeping. Two thumbs up!"

• Tammy...
• Taken for 1 to 6 months
• November 29, 2014

"I've had the side effects of nausea, diarrhea and low sex drive. Even so, it has helped improve my mood and reduced my anxiety. The side effects have decreased in the past few weeks but at first were bothersome. Largest complaint is the copay! Our cost is $122 after insurance! Outrageous. I probably wont be able to afford it for long. Sad because I finally found something that was working."

• Leah
• Taken for 1 to 6 months
• February 12, 2020

"After 2+ months being on Trintellix (10 mg), I am weaning myself off as quickly as possible. The side effects have been almost unbearable for me and my family. Daily feelings of nausea and frequent vomiting were bad enough, but the significant irritability and difficulty getting a deep breath were increasing and were the final straw for me!! I ended up in the ER 3 weeks ago because I was struggling to get a deep breath. After thorough testing, it was determined nothing was wrong. Deep search on Trintellix side effects made it clear the problem was this medication. I am now taking every other day until next week when I meet with my doctor. I hope no one else responds to this drug as badly as me! Take care! I definitely received no improvement in my depression and only major side effects that I can't live with."

• Coach
• Taken for 2 to 5 years
• August 14, 2018

"For years I’ve experienced various forms of depression including post partum (PMDD), and MDD. My treatment regimen has included SSRI, SNRI and Wellbutrin. To my dismay none of these agents seemed work for me and as a result, my depression relapsed and my episodes were greater, even to the point of suicidal thoughts. Often times I would have talks with my psychiatrist that while being on the prescribed medicine, “ I don’t know how I’m supposed to feel.” Come to find out later these feelings were a result of the medication not helping me. After a few years of complete misery and helplessness, Brintellix came along. My world changed. Within the first week I was feeling complete. I was sleeping well, had more energy and I also found interest in things again. The biggest improvement was my focus and concentration. More than 3 years later, I’m still in this drug and experienced absolutely no side effects."

• apath...
• March 9, 2015

"1 month in and I'm tolerating this medicine really well. I have Bipolar Disorder, but I'm taking it for depression and anxiety. I'm currently taking 10mg. I have occasional diarrhea and nightmares (may be the Lamotrigne), but that's it. So far I'm feeling more optimistic, I'm making plans for the future, I want to go out and socialize more often, and feel much more calm. I've tried more antidepressants than I can count and have been taking them since 1991. This is by far the best so far."

• Jeffrie...
• July 9, 2015

"It is... amazing. I have been on antidepressants on and off since i was 16 years old. I am now 19 any my life has completely changed around. My sleep is better, my appetite normal, my mood heightened, anxiety is away, and I don't feel as if there's something weighing down my heart. Please, if you are depressed right now, I highly recommend this medication. My dad has been using it too and he is genuinely happier with his life; i can see it in his eyes."

• Xaney
• October 16, 2016

"My Doctor gave me Trintellex recently for MDD And Anxiery Disorder. I was on viibyrd on and off for 3 yrs and it was not working for me anymore. I started Trintellex at 5mg for 7 days and now on 10 mgs, Day 5. I'm not crying anymore, my anxiety level is almost nothing and I feel happier. The only side effects I got was nauseated after taking the medicine for about an hour and itchy. I had to take a benedryl. These pass after about two weeks. I do not feel clouded like most other ssri make you feel or tired. I just feel normal! I think this is a great Medication."

• JC28
• January 21, 2019

"I’ve been on Trintellix 10mg daily for about four years; this last Spring of ‘18, I upped to 20mg. I felt my depression was getting bad again. I did see improvements with the higher dosage. I also take Propranolol daily for anxiety, which has helped significantly. In the last three months, my depression and anxiety symptoms have returned almost full force. I just started reading about side effects with both meds, and am putting some important pieces together. Within six months of beginning Trintellix, I began experiencing constipation, stomach pains, and mild joint pain. The symptoms were so bad, my Dr had my gall bladder removed. Nothing has changed. Now, I can’t help but connect the symptoms to Trintellix- can’t be 100% sure, though. Trintellix served me well for a period of time, but as usual, I’ve developed a resistance and need to search out another option. I hope this is helpful to those looking for more info on possible use of this Rx."

• Bobcat
• February 1, 2015

"This medicine is amazing! I was on Viibryd for 2 years and still suffered, but now I feel "normal" and am interested in life once again. I do have nausea and have trouble falling asleep, but those are tolerable; depression is difficult to tolerate."

• Augus...
• Taken for less than 1 month
• November 13, 2018

"I have been taking 10 mg for a week and no side effects whatsoever. For the first time in years I am sleeping through the night (I take it at bedtime) and wake up rested. It's not meant to be sleep aide, but it certainly is a nice side effect. With my anxiety and depression, I'm usually up at 2:00 am and wandering around my house for a few hours so this is a welcome change. I'm only seeing marginal increase in my depression but I suspect, being that I am tolerating it very well, I will get bumped up to a higher dose. The only potential side effect (I say potential because it's only been a week) is that my appetite is not as good as normal (forgetting to eat meals and when do, feel full much quicker). Will update as I move up in dosage."

• Dee
• Taken for less than 1 month
• July 3, 2019

"I have switched to Trintellix about 2 weeks ago from Celexa, which I had been on for 10+ years. My sex drive is back, more vivid, colorful dreams and just feeling so much more positive thoughts and overall good feeling!"

• Anonymous
• Taken for less than 1 month
• October 17, 2017

"If you have been struggling with unsuccessful medications for years, you need to go get genetic testing. Do it. This is a fairly recent development which I just found out about two months ago, after taking various medications for depression and anxiety for 15 years. My genetic test results indicate that I have 4 gene mutations that make the use of SSRIs and SNRIs ineffective. And of course, those are the medications I have been taking since the onset of my depression. So I am making the switch to Trintellix. Too early to say if this will be the right medication for me, but it is a comfort to know I am at least now working with my genetics instead of against them. Genetic testing is not the silver bullet, but it is valuable data. Do it."

• Tracy
• Taken for 6 months to 1 year
• September 6, 2017

"I've been on Trintellix 20 mg x 10 months, 53-year-old female with long-standing, chronic MDD & anxiety since pre-teen years. Been on far too many antidepressants over the decades to list them all here. Been hospitalized a number of times & in my 30's, resorted to ECT as a last resort, which did absolutely nothing. My psychiatrist says my MDD is very treatment-resistant. Antidepressants, even in high doses, or combined, have no effect. But I do believe for once in my life, the Trintellix is making some difference for the better in me; hasn't been a "miracle" drug, but it does help! No nausea or side effects, either! Also on Xanax, trazodone for sleep, & 10 mg Adderall daily."

• SDano
• Taken for 1 to 6 months
• February 20, 2020

"Hello everyone! I started trintellix in the middle of January at 5 mg. The side effects were horrible. I remember that on the second day I vomited on the street while I was having a walk. I also had other side effects. After the first week, things started to change slowly for the better. After the second week, I took 10 mg. During the six week when I broke up with my boyfriend and everything felt apart. The medication stopped working and my depression got worse. I was on the way to kill myself. Everything was so serious and I decided to go back to my home town where is my family and therapist. For 3 weeks I have been on Effexor XR and I cannot say I see a positive change but I feel hopeful that things will change for the better. I rate Trintelix with 2 because it had awful side effects and it didn't help me at the end. I wish luck to everyone reading this. You are not alone!"

• MrsG
• Taken for 6 months to 1 year
• December 28, 2019

"So Trintellix was weird for me. 20mgs worked well for my depression but triggered some awful OCD episodes. If you have OCD or anxiety, you might want to stay away from this one. The nausea was not fun. Even when taken with a dose of Zofran (anti nausea pill), my stomach would gurgle and churn all morning. I also had insomnia and when I finally did fall asleep, I’d have weird and sometimes disturbing dreams. Positive things about it. I didn’t gain any weight and had no sexual side effects. Antidepressants are all different and this particular one didn’t really work for me. But I will try as many as I have to until I find something that works."

• Autumn
• Taken for 1 to 2 years
• April 5, 2019

"I’ve read many of these posts. I too had nausea (would throw up within 15 minutes of taking Trintellix pill, every single day). My doctor told me to take an anti-nausea med like Zofran (or generic) 30 minutes before I take this pill. It worked. No nausea at all if you follow that rule. Please try that if that’s your only hold up. I’ve been on it about 2 years. I STILL have to take a Zofran 30 minutes before Trintellix or I will puke. Also, take it around bedtime."