Medication Guide App

Voriconazole

Pronunciation

Generic Name: voriconazole (VOR-i-KON-a-zole)
Brand Name: Vfend

Voriconazole is used for:

Treating certain fungal infections.

Voriconazole is an azole antifungal. It works by blocking fungal cell wall growth, which results in the death of the fungus.

Do NOT use voriconazole if:

  • you are allergic to any ingredient in voriconazole
  • you have untreated low blood calcium, magnesium, or potassium levels
  • you are taking astemizole, a barbiturate (eg, phenobarbital), carbamazepine, cisapride, an ergot alkaloid (eg, dihydroergotamine, ergotamine), everolimus, fluconazole, pimozide, quinidine, rifabutin, rifampin, sirolimus, St. John's wort, or terfenadine

Contact your doctor or health care provider right away if any of these apply to you.

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Before using voriconazole:

Some medical conditions may interact with voriconazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to other azole antifungals (eg, fluconazole, itraconazole)
  • if you have a history of heart problems (eg, cardiomyopathy, slow or irregular heartbeat); an abnormal electrocardiogram (ECG) (a type of heart test); or low blood calcium, magnesium, or potassium levels
  • if you have liver problems (eg, cirrhosis), kidney problems, pancreas problems, a weakened immune system, or a blood disease (eg, blood or bone marrow cancer)
  • if you have ever been on chemotherapy or have had a stem cell transplant
  • if you have taken fluconazole within the last 24 hours
  • if you are taking ritonavir. Voriconazole should not be taken with certain doses of ritonavir

Some MEDICINES MAY INTERACT with voriconazole. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Medicines that may harm the kidney because the risk of kidney side effects may be increased. Ask your doctor or pharmacist if you are unsure if any of your medicines might affect the kidney
  • Medicines that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat
  • Many other prescription and nonprescription medicines (eg, used for aches and pains, anxiety, birth control, blood flow problems, blood thinning, cancer, diabetes, drug dependence, heartburn or reflux, high blood pressure, high cholesterol, HIV, immune system suppression, infections, irregular heartbeat or other heart problems, mental or mood problems, pain, seizures, stomach or bowel problems), multivitamin products, or herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with voriconazole. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with voriconazole

This may not be a complete list of all interactions that may occur. Ask your health care provider if voriconazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use voriconazole:

Use voriconazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with voriconazole. Talk to your pharmacist if you have questions about this information.
  • Voriconazole is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • If you miss a dose of voriconazole, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use voriconazole.

Important safety information:

  • Tell your doctor or dentist that you take voriconazole before you receive any medical or dental care, emergency care, or surgery.
  • Voriconazole may cause blurred vision or sensitivity to light. These effects may be worse if you take it with alcohol or certain medicines. Use voriconazole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Avoid driving at night while you are using voriconazole.
  • Voriconazole may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to voriconazole. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Uncommonly, some patients have experienced a reaction while receiving voriconazole. Tell your doctor right away if you develop flushing, fever, sweating, fast heartbeat, chest tightness, shortness of breath, faintness, nausea, itching, or rash while you are receiving voriconazole.
  • Certain types of skin cancers (eg, melanoma, squamous cell) have been reported in patients who became sensitive to sunlight while taking voriconazole for a long period of time. Contact your doctor if you notice a change in the appearance of a mole or other unusual skin change or growth. Discuss any questions or concerns with your doctor.
  • Voriconazole may make your eyes more sensitive to sunlight. It may help to wear sunglasses. Avoid strong, direct sunlight.
  • Serious and sometimes fatal liver problems have happened with voriconazole. Call your doctor right away if you have symptoms of liver problems (eg, dark urine; itching; pale stools; persistent loss of appetite; severe or persistent nausea, vomiting, or stomach pain; yellowing of the skin or eyes).
  • A severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause serious health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • If your symptoms do not get better within a few days or if they get worse, check with your doctor.
  • Women who may become pregnant should use effective birth control (eg, birth control pills) while using voriconazole. Talk with your doctor if you have questions about effective birth control.
  • Lab tests, including eye exams, liver and kidney function, and pancreas function, may be performed while you use voriconazole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Caution is advised when using voriconazole in CHILDREN; they may be more sensitive to its effects, especially sunburn or skin reactions to light.
  • PREGNANCY and BREAST-FEEDING: Voriconazole may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using voriconazole while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking voriconazole.

Possible side effects of voriconazole:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thoughts; black, tarry stools; bone pain; calf or leg pain, redness, swelling, or tenderness; change in the appearance of a mole; chest, jaw, or arm pain; confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; flushing; hallucinations; mental or mood changes (eg, depression); mouth sores; one-sided weakness; seizures; severe or persistent dizziness or headache; shortness of breath; speech changes; sudden, severe nausea or vomiting; suicidal thoughts or actions; sunburn or skin reaction to light; swelling of the arms or legs; symptoms of kidney problems (eg, unable to pass urine, change in the amount of urine passed, blood in the urine, big weight gain); symptoms of pancreatitis (eg, severe stomach or back pain, with or without nausea or vomiting); unusual bruising or bleeding; unusual skin change or skin growth; unusual sweating or weakness; unusual tiredness; unusual vaginal bleeding; vision changes (eg, color vision change, persistent or severe blurred vision or sensitivity to light).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of voriconazole:

Voriconazole is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

General information:

  • If you have any questions about voriconazole, please talk with your doctor, pharmacist, or other health care provider.
  • Voriconazole is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take voriconazole or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about voriconazole. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to voriconazole. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using voriconazole.

Issue Date: April 1, 2015
Database Edition 15.2.1.001
Copyright © 2015 Clinical Drug Information, LLC

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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