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Vaprisol

Generic Name: conivaptan (KOE-ni-VAP-tan)
Brand Name: Vaprisol

Vaprisol is used for:

Treating low blood sodium levels in certain patients.

Vaprisol is an arginine vasopressin receptor antagonist. It works by increasing fluid removal from the body, which helps to normalize blood sodium levels.

Do NOT use Vaprisol if:

  • you are allergic to any ingredient in Vaprisol or to corn or corn products
  • you have low blood sodium levels along with low blood or fluid volume
  • you have severe kidney problems or you are not able to urinate
  • you are taking certain azole antifungals (eg, ketoconazole, itraconazole), an HIV protease inhibitor (eg, indinavir, ritonavir), certain macrolide antibiotics (eg, clarithromycin), nefazodone, or telithromycin

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Vaprisol:

Some medical conditions may interact with Vaprisol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have congestive heart failure, liver problems, or kidney problems
  • if you have poor nutrition or you have an alcohol addiction

Some MEDICINES MAY INTERACT with Vaprisol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azole antifungals (eg, itraconazole, ketoconazole), HIV protease inhibitors (eg, indinavir, ritonavir), macrolides (eg, clarithromycin), nefazodone, or telithromycin because they may increase the risk of Vaprisol's side effects
  • Amlodipine, benzodiazepines (eg, alprazolam, midazolam), or digoxin because the risk of their side effects may be increased by Vaprisol
  • HMG-CoA reductase inhibitors (eg, atorvastatin) because the risk of serious muscle problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vaprisol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Vaprisol:

Use Vaprisol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Vaprisol is given as an injection at your doctor's office, hospital, or clinic.
  • Do not use Vaprisol if it contains particles, is cloudy or discolored, or if the container is cracked or damaged.
  • If you miss a dose of Vaprisol, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Vaprisol.

Important safety information:

  • Vaprisol may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Vaprisol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Vaprisol may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Severe side effects may occur if your blood sodium levels rise too quickly. Contact your doctor right away if you develop abnormal speech (eg, you are unable to speak), trouble swallowing, mental or mood changes, seizures, sluggishness, or weakness in the arms and legs.
  • Diabetes patients - Vaprisol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including blood sodium levels and neurologic tests, may be performed while you use Vaprisol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Vaprisol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Vaprisol may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Vaprisol while you are pregnant. It is not known if Vaprisol is found in breast milk. Do not breast-feed while taking Vaprisol.

Possible side effects of Vaprisol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dry mouth; headache; increased thirst; nausea; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; confusion; drowsiness; fast or irregular heartbeat; fever; increased or painful urination; increased sweating; mental or mood changes; muscle pain, weakness, or cramping; pain, irritation, redness, or swelling at the injection site; rapid breathing; severe or persistent dizziness; severe or persistent increase in thirst; tremor; unusual tiredness or weakness; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org ), or emergency room immediately. Symptoms may include fainting; severe or persistent dizziness; severe or persistent increase in thirst.

Proper storage of Vaprisol:

Vaprisol is usually handled and stored by a health care provider. If you are using Vaprisol at home, store Vaprisol as directed by your pharmacist or health care provider. Keep Vaprisol out of the reach of children and away from pets.

General information:

  • If you have any questions about Vaprisol, please talk with your doctor, pharmacist, or other health care provider.
  • Vaprisol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Vaprisol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Vaprisol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Vaprisol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Vaprisol.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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