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Sinequan concentrate

Pronunciation

Generic Name: doxepin (DOX-e-pin)
Brand Name: Sinequan

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Sinequan concentrate outweigh the risks.

Family and caregivers must closely watch patients who take Sinequan concentrate. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Sinequan concentrate is not approved for use in children. Talk with the doctor.


Sinequan concentrate is used for:

Treating depression or anxiety in certain patients. It may also be used for other conditions as determined by your doctor.

Sinequan concentrate is a tricyclic antidepressant. Exactly how it works is not known. It may increase the activity of certain chemicals in the brain that help elevate mood.

Do NOT use Sinequan concentrate if:

  • you are allergic to any ingredient in Sinequan concentrate or to other tricyclic antidepressants
  • you have glaucoma or trouble urinating
  • you have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, furazolidone, phenelzine, isocarboxazid) within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Sinequan concentrate:

Some medical conditions may interact with Sinequan concentrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems, seizures (eg, epilepsy), overactive thyroid, prostate problems (eg, benign prostatic hypertrophy [BPH]), blood problems (eg, porphyria), increased eye pressure, other mental or mood problems, suicidal thoughts or attempts, or alcohol abuse
  • if you are taking a medicine that contains methylene blue

Some MEDICINES MAY INTERACT with Sinequan concentrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, quinidine, propafenone, flecainide), antifungal medicines (eg, fluconazole, terbinafine), carbamazepine, cimetidine, mibefradil, phenothiazines (eg, chlorpromazine, thioridazine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, sertraline) because they may increase the risk of Sinequan concentrate's side effects
  • Anticoagulants (eg, warfarin), H1 antagonists (eg, astemizole, terfenadine), ibutilide, sulfonylureas (eg, tolazamide, glipizide), sympathomimetics (eg, phenylephrine, pseudoephedrine), or tramadol because the risk of their side effects may be increased by Sinequan concentrate
  • Clonidine, guanadrel, guanethidine, or guanfacine because their effectiveness may be decreased by Sinequan concentrate
  • Linezolid or MAOIs (eg, furazolidone, phenelzine, isocarboxazid) because severe toxic effects may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sinequan concentrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sinequan concentrate:

Use Sinequan concentrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Sinequan concentrate by mouth with or without food.
  • Sinequan concentrate must be diluted before taking. Dilute Sinequan concentrate in 4 oz (120 mL) of water, milk, or fruit juice.
  • Taking Sinequan concentrate at bedtime may help reduce side effects (eg, daytime drowsiness). Discuss this possibility with your doctor.
  • If you miss a dose of Sinequan concentrate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you take 1 dose daily at bedtime, do not take the missed dose the next morning.

Ask your health care provider any questions you may have about how to use Sinequan concentrate.

Important safety information:

  • Sinequan concentrate may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sinequan concentrate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Sinequan concentrate may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Sinequan concentrate; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Children, teenagers, and young adults who take Sinequan concentrate may be at increased risk for suicidal thoughts or actions. Watch all patients who take Sinequan concentrate closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Some people may be at risk for eye problems from Sinequan concentrate. Your doctor may want you to have an eye exam to see if you are at risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, or swelling or redness in or around the eye.
  • Sinequan concentrate may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sinequan concentrate. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Sinequan concentrate before you receive any medical or dental care, emergency care, or surgery.
  • After you start taking Sinequan concentrate, several weeks may pass before you feel the full benefit.
  • Taking Sinequan concentrate at bedtime may help reduce side effects (eg, daytime drowsiness). Discuss this possibility with your doctor.
  • Use Sinequan concentrate with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sinequan concentrate while you are pregnant. Sinequan concentrate is found in breast milk. Do not breast-feed while taking Sinequan concentrate.

Possible side effects of Sinequan concentrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; constipation; diarrhea; dizziness; drowsiness; dry mouth; excess sweating; headache; heartburn; increased appetite; indigestion; nausea; unpleasant taste; urinary retention; vomiting; weakness; weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal movements; aggressive or bizarre behavior; agitation; anxiety; chest pain; difficulty speaking and swallowing; disorientation; eye pain; fainting; fast, slow, or irregular heartbeat; hair loss; hallucinations; hostility; irritability; loss of balance; mood swings; nervousness or restlessness; panic attacks; ringing in the ears; seizures; shakiness; sore throat or fever; trouble sleeping; twitching of the face or tongue; unusual bleeding or bruising; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Sinequan concentrate:

Store Sinequan concentrate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Sinequan concentrate out of the reach of children and away from pets.

General information:

  • If you have any questions about Sinequan concentrate, please talk with your doctor, pharmacist, or other health care provider.
  • Sinequan concentrate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Sinequan concentrate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Sinequan concentrate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Sinequan concentrate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Sinequan concentrate.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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