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Doxepin Pregnancy and Breastfeeding Warnings

Doxepin is also known as: Adapin, Silenor, Sinequan

Doxepin Pregnancy Warnings

Doxepin has not been formally assigned to a pregnancy category. Animal studies failed to reveal evidence of teratogenicity. One human infant whose mother took doxepin and a variety of other psychotropic agents was born with a small left colon. There are no controlled data in human pregnancy. Doxepin should only be given during pregnancy when benefit outweighs risk.

See references

Doxepin Breastfeeding Warnings

Doxepin is excreted into human milk in small amounts. Respiratory depression has been reported in one breast-fed infant. The American Academy of Pediatrics classifies doxepin as a drug "whose effect on nursing infants is unknown but may be of concern".

See references

References for pregnancy information

  1. "Product Information. Sinequan (doxepin)." Roerig Division, New York, NY.
  2. Falterman CG, Richardson CJ "Small left colon syndrome associated with maternal ingestion of psychotropic drugs." J Pediatr 97 (1980): 308-10
  3. Llewellyn A, Stowe ZN "Psychotropic medications in lactation." J Clin Psychiatry 59 Suppl 2 (1998): 41-52

References for breastfeeding information

  1. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  2. Matheson I, Pande H, Alertsen AR "Respiratory depression caused by N-desmethyldoxepin in breast milk ." Lancet 2 (1985): 1124
  3. Llewellyn A, Stowe ZN "Psychotropic medications in lactation." J Clin Psychiatry 59 Suppl 2 (1998): 41-52
  4. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
  5. Kemp J, Ilett KF, Booth J, Hackett LP "Excretion of doxepin and N-desmethyldoxepin in human milk." Br J Clin Pharmacol 20 (1985): 497-9
  6. Frey OR, Scheidt P, vonBrenndorff AI "Adverse effects in a newborn infant breast-fed by a mother treated with doxepin." Ann Pharmacother 33 (1999): 690-3
  7. "Product Information. Sinequan (doxepin)." Roerig Division, New York, NY.

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