Measles, mumps, rubella, and varicella vaccine

Generic Name: measles, mumps, rubella, and varicella vaccine (MEE-zills, mumps, rue-BELL-a, ver-i-SELL-a)
Brand Name: ProQuad

Measles, mumps, rubella, and varicella vaccine is used for:

Preventing measles, mumps, rubella, and varicella (chickenpox).

Measles, mumps, rubella, and varicella vaccine is a vaccine. It stimulates the body to produce antibodies against infection of measles, mumps, rubella, or chickenpox.

Do NOT use measles, mumps, rubella, and varicella vaccine if:

  • you are allergic to any ingredient in measles, mumps, rubella, and varicella vaccine, including gelatin
  • you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to neomycin
  • you have a weakened immune system (eg, advanced HIV, AIDS, decreased gamma globulin levels, decreased white blood cell levels), blood problems, cancer affecting the blood or bone marrow (eg, leukemia), fever, or active or untreated tuberculosis (TB)
  • you are pregnant
  • you are taking an immunosuppressant (eg, cyclosporine) or a salicylate (eg, aspirin)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using measles, mumps, rubella, and varicella vaccine:

Some medical conditions may interact with measles, mumps, rubella, and varicella vaccine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to eggs
  • if you have an infection, a tumor, HIV, low blood platelet levels, a history of seizures or head injury, or a family history of seizures or immune system weakness
  • if you have had a recent blood or plasma transfusion or have received immune globulin or a tuberculin test
  • if you have been exposed to measles, mumps, rubella, or chickenpox
  • if you have a history of tuberculosis

Some MEDICINES MAY INTERACT with measles, mumps, rubella, and varicella vaccine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Corticosteroids (eg, prednisone) or immunosuppressants (eg, cyclosporine) because the effectiveness of measles, mumps, rubella, and varicella vaccine may be decreased
  • Salicylates (eg, aspirin) because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if measles, mumps, rubella, and varicella vaccine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use measles, mumps, rubella, and varicella vaccine:

Use measles, mumps, rubella, and varicella vaccine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Measles, mumps, rubella, and varicella vaccine is administered as an injection at your doctor's office, hospital, or clinic. Ask your doctor any questions that you may have about measles, mumps, rubella, and varicella vaccine.
  • If you miss a dose of measles, mumps, rubella, and varicella vaccine, contact your doctor to set up a new dosing schedule.

Ask your health care provider any questions you may have about how to use measles, mumps, rubella, and varicella vaccine.

Important safety information:

  • Measles, mumps, rubella, and varicella vaccine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to measles, mumps, rubella, and varicella vaccine. Using measles, mumps, rubella, and varicella vaccine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Measles, mumps, rubella, and varicella vaccine may decrease the effectiveness of tuberculin tests. If you are scheduled to have a tuberculin test within 6 weeks after receiving this vaccination, contact your doctor. You may need to reschedule your tuberculin test.
  • Avoid contact with individuals with weakened immune systems, pregnant women who have not had chickenpox, and newborns whose mothers have not had chickenpox for 6 weeks after receiving this vaccination.
  • Avoid use of salicylates (eg, aspirin) for 6 weeks after receiving this vaccination.
  • Keep written documentation of all vaccinations received to help avoid unnecessary doses. Be sure that your doctor knows the dates that you have received other vaccinations.
  • This vaccine may not guarantee protection against measles, mumps, rubella, or chickenpox. Discuss any questions or concerns with your doctor.
  • Adult women may experience joint pain 2 to 4 weeks after receiving this injection. This usually lasts only a short time. However, these symptoms have persisted for months or, rarely, years.
  • Measles, mumps, rubella, and varicella vaccine contains albumin, which comes from human blood. There is an extremely rare risk of developing a viral disease, or a central nervous system disease called Creutzfeldt-Jakob disease. No cases of viral diseases or Creutzfeldt-Jakob disease from albumin have been identified.
  • Use measles, mumps, rubella, and varicella vaccine with extreme caution in CHILDREN younger than 12 months of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use measles, mumps, rubella, and varicella vaccine if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. After receiving measles, mumps, rubella, and varicella vaccine, do not become pregnant for at least 3 months without checking with your doctor. It is unknown if measles, mumps, rubella, and varicella vaccine is excreted in breast milk. Do not breast-feed while using measles, mumps, rubella, and varicella vaccine.

Possible side effects of measles, mumps, rubella, and varicella vaccine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; fever; general unwell feeling; headache; irritability; mild rash; muscle or joint ache or pain; nausea; pain, tenderness, soreness, or swelling at the injection site; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; loss of coordination; mental or mood changes; numbness or tingling in the fingers or toes; red, swollen, blistered, or peeling skin; seizures; unusual bruising or bleeding; vision or hearing changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of measles, mumps, rubella, and varicella vaccine:

Measles, mumps, rubella, and varicella vaccine is usually handled and stored by a health care provider. If you are using measles, mumps, rubella, and varicella vaccine at home, store measles, mumps, rubella, and varicella vaccine as directed by your pharmacist or health care provider. Keep measles, mumps, rubella, and varicella vaccine out of the reach of children and away from pets.

General information:

  • If you have any questions about measles, mumps, rubella, and varicella vaccine, please talk with your doctor, pharmacist, or other health care provider.
  • Measles, mumps, rubella, and varicella vaccine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take measles, mumps, rubella, and varicella vaccine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about measles, mumps, rubella, and varicella vaccine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to measles, mumps, rubella, and varicella vaccine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using measles, mumps, rubella, and varicella vaccine.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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