Hepatitis b immune globulin

Generic Name: hepatitis b immune globulin (hep-ah-TY-tiss B ih-MYOON GLAH-bu-lin)
Brand Name: Examples include BayHep B and Nabi-HB

Hepatitis b immune globulin may increase the risk of blood clots. The risk may be increased in older patients, if you will be confined to a bed or chair for a period of time, if you take estrogen products, or if you have certain catheters. The risk may also be increased if you have a condition that may increase your risk of blood clots, thick blood, heart problems, or a history of blood clots. Blood clots can occur if you do not have any of these conditions. Tell your doctor right away if you develop one-sided numbness or weakness; pain, redness, tenderness, warmth or swelling in the arms or legs; change in color of an arm or leg; chest pain or discomfort; shortness of breath; fast heartbeat; or coughing up blood. Discuss any questions or concerns with your doctor.


Hepatitis b immune globulin is used for:

Preventing hepatitis B infection after exposure to the virus.

Hepatitis b immune globulin is an immunizing agent. It works by temporarily increasing the antibody concentration, which helps protect against hepatitis B infection.

Do NOT use hepatitis b immune globulin if:

  • you are allergic to any ingredient in hepatitis b immune globulin

Contact your doctor or health care provider right away if any of these apply to you.

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Before using hepatitis b immune globulin:

Some medical conditions may interact with hepatitis b immune globulin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had an allergic reaction to medicines made with human immune globulin
  • if you have a blood disorder (eg, decreased blood platelets) or any other blood-clotting disorder

Some MEDICINES MAY INTERACT with hepatitis b immune globulin. However, no specific interactions with hepatitis b immune globulin are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if hepatitis b immune globulin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use hepatitis b immune globulin:

Use hepatitis b immune globulin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Hepatitis b immune globulin is usually administered as an injection at your doctor's office, hospital, or clinic. Ask your doctor or pharmacist any questions that you may have about hepatitis b immune globulin.
  • If you miss a dose of hepatitis b immune globulin, contact your doctor right away.

Ask your health care provider any questions you may have about how to use hepatitis b immune globulin.

Important safety information:

  • Hepatitis b immune globulin is made from human plasma and carries a slight risk of containing viruses that may cause disease. Ask your doctor any questions that you may have about the risks and benefits of using hepatitis b immune globulin.
  • To prevent hepatitis B infection, more than 1 dose of hepatitis b immune globulin may be required. Be sure you receive all of the recommended injections.
  • Check with your doctor before having vaccinations for mumps, rubella, or hepatitis for 3 months after you have received hepatitis b immune globulin.
  • Tell your doctor if you have ever been vaccinated for hepatitis.
  • Hepatitis b immune globulin is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using hepatitis b immune globulin during pregnancy. It is unknown if hepatitis b immune globulin is excreted in breast milk. If you are or will be breast-feeding while you are using hepatitis b immune globulin, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of hepatitis b immune globulin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; loss of appetite; nausea; pain, redness, or swelling at the injection site; slight fever.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of hepatitis b immune globulin:

Hepatitis b immune globulin is usually handled and stored by a health care provider. If you are using hepatitis b immune globulin at home, store hepatitis b immune globulin as directed by your pharmacist or health care provider. Keep hepatitis b immune globulin out of the reach of children and away from pets.

General information:

  • If you have any questions about hepatitis b immune globulin, please talk with your doctor, pharmacist, or other health care provider.
  • Hepatitis b immune globulin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take hepatitis b immune globulin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about hepatitis b immune globulin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to hepatitis b immune globulin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using hepatitis b immune globulin.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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