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Choriogonadotropin alfa

Generic Name: choriogonadotropin alfa (KORE-ee-oh-goe-NAD-oh-TROE-pin AL-fa)
Brand Name: Ovidrel

Choriogonadotropin alfa is used for:

Treating infertility in certain women who have not gone through menopause. It may also be used for other conditions as determined by your doctor.

Choriogonadotropin alfa is a hormone. Human chorionic gonadotropin (HCG) helps to produce mature eggs in women undergoing fertility procedures, such as in vitro fertilization, and it also stimulates ovulation (release of an egg).

Do NOT use choriogonadotropin alfa if:

  • you are allergic to any ingredient in choriogonadotropin alfa
  • you have abnormal bleeding of the uterus of unknown cause, brain lesion or tumor (eg, pituitary gland tumor), primary ovarian failure, enlarged ovary or ovarian cyst of unknown cause, uncontrolled thyroid or adrenal gland problems, or tumors in the reproductive tract or liver that are sex hormone-dependent
  • if you are pregnant

Contact your doctor or health care provider right away if any of these apply to you.

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Before using choriogonadotropin alfa:

Some medical conditions may interact with choriogonadotropin alfa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have adrenal gland disease, bleeding in the reproductive or urinary tract, blockage of the fallopian tubes, or thyroid disease
  • if you are very overweight, will be having surgery, or will be confined to a bed or chair for a period of time
  • if you or a member of your family have or have ever had blockage of blood vessels (blood clots) in the legs, lungs, or other parts of the body

Some MEDICINES MAY INTERACT with choriogonadotropin alfa. However, no specific interactions with choriogonadotropin alfa are known at this time.

Ask your health care provider if choriogonadotropin alfa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use choriogonadotropin alfa:

Use choriogonadotropin alfa as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Choriogonadotropin alfa is given as an injection under the skin. A health care provider will teach you how to use it. Be sure you understand how to use choriogonadotropin alfa. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Choriogonadotropin alfa comes in a single-use syringe. Wash your hands with soap and water before you begin. Wipe the appropriate injection site with an alcohol swab. Remove the cap from the needle of the syringe. Do not touch the needle or allow the needle to touch anything else. Use the technique you have been shown to give the injection. After giving the injection, cover the injection site with a small bandage if necessary. Discard all used material appropriately.
  • Do not use choriogonadotropin alfa if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of choriogonadotropin alfa, contact your doctor right away.

Ask your health care provider any questions you may have about how to use choriogonadotropin alfa.

Important safety information:

  • Choriogonadotropin alfa may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use choriogonadotropin alfa with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • You must receive a thorough gynecological exam before beginning treatment with choriogonadotropin alfa.
  • Use of choriogonadotropin alfa can increase your risk of multiple births, blood clots, enlarged ovaries, and ruptured ovarian cysts. Discuss these risks with your doctor.
  • Ovarian hyperstimulation syndrome (OHSS) is a severe side effect that may occur in some women who use choriogonadotropin alfa. Contact your doctor right away if you develop severe stomach pain or bloating; nausea, vomiting, or diarrhea; sudden, unexplained weight gain; shortness of breath; or decreased urination.
  • Lab tests, including blood hormone levels and ultrasound exams, may be performed while you use choriogonadotropin alfa. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: Do not use choriogonadotropin alfa if you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if choriogonadotropin alfa is found in breast milk. If you are or will be breast-feeding while you use choriogonadotropin alfa, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of choriogonadotropin alfa:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; pain, swelling, bruising, or redness at the injection site; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloating or swelling in the stomach or pelvic area; breast pain; calf or leg pain, redness, swelling, or tenderness; chest pain; decreased urination; irregular heartbeat; persistent or severe nausea, vomiting, or diarrhea; severe pelvic pain; severe stomach pain or bloating; sudden shortness of breath; sudden, unexpected weight gain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of choriogonadotropin alfa:

Store choriogonadotropin alfa in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Choriogonadotropin alfa may also be stored at room temperature, up to 77 degrees F (25 degrees C), for up to 30 days. Protect from heat, moisture, and light. Throw choriogonadotropin alfa away after it has been stored for 30 days at room temperature. Keep choriogonadotropin alfa out of the reach of children and away from pets.

General information:

  • If you have any questions about choriogonadotropin alfa, please talk with your doctor, pharmacist, or other health care provider.
  • Choriogonadotropin alfa is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take choriogonadotropin alfa or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about choriogonadotropin alfa. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to choriogonadotropin alfa. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using choriogonadotropin alfa.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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