Cefaclor use while Breastfeeding
Drugs containing Cefaclor: Ceclor, Raniclor, Ceclor CD, Ceclor Pulvules
Cefaclor Levels and Effects while Breastfeeding
Summary of Use during Lactation
Cefaclor is acceptable to use during breastfeeding. Limited information indicates that maternal cefaclor produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.
Drug Levels
Maternal Levels. A single dose of cefaclor 250 mg was given orally to 2 nursing mothers. In one mother it was undetectable in milk. In the other, levels of 0.15 to 0.19 mg/L occurred 2 to 4 hours after the dose; by 5 hours it was undetectable. In 5 mothers who received a single 500 mg oral dose, an average peak level of 0.21 mg/L occurred 4 hours after the dose. In individual patients, peak levels of 0.18 to 0.35 mg/L occurred 2 to 5 hours after the dose.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In a telephone follow-up study, 5 nursing mothers reported taking cefaclor (dosage unspecified). One mother reported diarrhea in her infant. No rashes or candidiasis were reported among the exposed infants.[2]
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
References
1. Takase Z, Shirafuji H, Uchida M. Clinical and laboratory studies of cefaclor in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1979;27(Suppl 7):666-72.
2. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
Cefaclor Identification
Substance Name
CAS Registry Number
53994-73-3
Drug Class
- Antiinfective Agents
- Antibacterial Agents
- Cephalosporins
Administrative Information
LactMed Record Number
41
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2010-02-12
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Cefaclor use during Pregnancy
- Cefaclor Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
