... of application and the symptoms/effects are roughly the same. Red spots on face and neck. Some are new and some are in the same area as the the last round. Does not look appealing but clears up quickly after you stop using it. I apply post shower every morning. Before applying, I clean the area with 90% rubbing alcohol and despite the fact that some of the sores are open, this causes very little discomfort. Then apply to impacted areas. I expanded the area to use the entire contents of each packet with each use. Works well and no wasting this expensive drug. Shaving is an issue and I try to shave as little as possible and around the affected areas. I grew a goatee to help detract from the sores. Helps a little I guess.